SIRT1 Polyclonal Antibody | Invitrogen PA5-116530 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SIRT1 Polyclonal Antibody

catalog :

PA5-116530

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

SIRT1 Polyclonal Antibody

Catalog # :

PA5-116530

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 448-747 of human SIRT1 (NP_0363702)

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:5,000

Aliases :

75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1