NRXN3 Polyclonal Antibody | Invitrogen PA5-115673 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NRXN3 Polyclonal Antibody

catalog :

PA5-115673

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Product Type :

Antibody

Product Name :

NRXN3 Polyclonal Antibody

Catalog # :

PA5-115673

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (PFA fixed): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Neurexins comprise a family of neuronal cell surface proteins, which include neurexin I (NRXN1), neurexin II (NRXN2), neurexin III (NRXN3) and Caspr (neurexin IV). Neurexins I-III are expressed as a and b isoforms. The a isoforms are made of three cassettes, which contain two LNS (Laminin A, Neurexins, Sex hormone-binding)-domains separated by EGF domains, followed by a transmembrane region and a 55 amino acid cytoplasmic C-terminal. The a isoforms bind to neurexophilins at the second LNS site and to the excitatory neurotoxin a-latrotoxin. The b isoforms have only one LNS-domain, bind to neuroligins, and play a role in the formation and remodeling of synapes. Caspr (for Contactin-Associated Protein 1, also designated Paranodin in mouse), contains an extracellular domain similar to the other three neurexins, and binds to the surface glycoprotein Contactin. Caspr and the closely related Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), demarcate distinct subdomains in myelinated axons. Specifically, Caspr exists at the paranodal junctions, while Caspr2 colocalizes with Shaker-like K+ channels in the juxtaparanodal region. Caspr may play a role in the communication of glial cells and neurons during development.

Immunogen :

A synthesized peptide derived from human NRXN3(Accession Q9Y4C0), corresponding to amino acid residues N1060-R1110.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (PFA fixed): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Aliases :

C14orf60; KIAA0743; neurexin 3; Neurexin 3alpha; neurexin III; Neurexin III-alpha; Neurexin III-beta; Neurexin-3; neurexin-3-alpha; Neurexin-3-beta; Neurexin-3-beta, C-terminal fragment; Neurexin-3-beta, soluble form; Nrxn3; NRXN3-CTF