This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Caspase 3 (Cleaved Asp175) Polyclonal Antibody
catalog :
PA5-114687
quantity :
100 uL
price :
US 460.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 19
Reference
Yu F, Li L, Gu Y, Wang S, Zhou L, Cheng X, et al. Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression. Mol Med. 2024;30:9 pubmed publisher
Jin C, Yuan S, Piao L, Ren M, Liu Q. Propofol synergizes with circAPBB2 to protect against hypoxia/reoxygenation-induced oxidative stress, inflammation, and apoptosis of human cardiomyocytes. Immun Inflamm Dis. 2023;11:e952 pubmed publisher
Abdelrahman S, Khattab M, Youssef M, Mahmoud A. Granulocyte-colony stimulating factor ameliorates di-ethylhexyl phthalate-induced cardiac muscle injury via stem cells recruitment, Desmin protein regulation, antifibrotic and antiapoptotic mechanisms. J Mol Histol. 2023;54:349-363 pubmed publisher
Sui C, Zhou D. ADAM metallopeptidase domain 10 knockdown enables podocytes to resist high glucose stimulation by inhibiting pyroptosis via MAPK pathway. Exp Ther Med. 2023;25:260 pubmed publisher
Zhao L, Fan J, Zhang C, Zhang Z, Dong J. CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p. Open Med (Wars). 2023;18:20230672 pubmed publisher
Jin X, Zheng W, Chi S, Cui T, He W. miR-506-3p Relieves Neuropathic Pain following Brachial Plexus Avulsion via Mitigating Microglial Activation through Targeting the CCL2-CCR2 Axis. Dev Neurosci. 2023;45:37-52 pubmed publisher
Hamdalla H, Ahmed R, Galaly S, Naguib I, Alghamdi B, Ahmed O, et al. Ameliorative Effect of Curcumin Nanoparticles against Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats. Mediators Inflamm. 2022;2022:8353472 pubmed publisher
Tvrd xe1 E, Kov xe1 x10d J, Ferenczyov xe1 K, Kalo x10d ayov xe1 B, x10e ura x10d ka M, Benko F, et al. Quercetin Ameliorates Testicular Damage in Zucker Diabetic Fatty Rats through Its Antioxidant, Anti-Inflammatory and Anti-Apoptotic Properties. Int J Mol Sci. 2022;23: pubmed publisher
Liang M, Zhu X, Zhang D, He W, Zhang J, Yuan S, et al. Yi-Shen-Hua-Shi granules inhibit diabetic nephropathy by ameliorating podocyte injury induced by macrophage-derived exosomes. Front Pharmacol. 2022;13:962606 pubmed publisher
Balkrishna A, Mulay V, Verma S, Srivastava J, Lochab S, Varshney A. Penta-O-Galloyl-β-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells. Front Pharmacol. 2022;13:889335 pubmed publisher
Tsui M, Biro J, Chan J, Min W, Dobbs K, Notarangelo L, et al. Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons. Sci Rep. 2022;12:9084 pubmed publisher
Liang Z, He P, Han Y, Yun C. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling. Cell Mol Gastroenterol Hepatol. 2022;14:129-150 pubmed publisher
Mortoglou M, Manić L, Buha Djordjevic A, Bulat Z, Đorđević V, Manis K, et al. Nickel's Role in Pancreatic Ductal Adenocarcinoma: Potential Involvement of microRNAs. Toxics. 2022;10: pubmed publisher
Gao Y, Wang L, Niu Z, Feng H, Liu J, Sun J, et al. miR-340-5p inhibits pancreatic acinar cell inflammation and apoptosis via targeted inhibition of HMGB1. Exp Ther Med. 2022;23:140 pubmed publisher
Wang J, Shen J. LncRNA HOXA11-AS aggravates the keloid formation by targeting miR-148b-3p/IGFBP5 axis. Biochem Biophys Res Commun. 2021;581:60-67 pubmed publisher
Chen H, Wei L, Luo M, Wang X, Zhan Y, Mao Y, et al. PAD4 inhibitor promotes DNA damage and radiosensitivity of nasopharyngeal carcinoma cells. Environ Toxicol. 2021;36:2291-2301 pubmed publisher
Hu X, Lou T, Yuan C, Wang Y, Tu X, Wang Y, et al. Effects of lncRNA ANRIL-knockdown on the proliferation, apoptosis and cell cycle of gastric cancer cells. Oncol Lett. 2021;22:621 pubmed publisher
Bao J, Qian Z, Liu L, Hong X, Che H, Wu X. Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells. Front Cell Dev Biol. 2021;9:675486 pubmed publisher
Huang C, Li R, Yang C, Ding R, Li Q, Xie D, et al. PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis. Exp Mol Med. 2021;53:894-906 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Caspase 3 (Cleaved Asp175) Polyclonal Antibody
Catalog # :
PA5-114687
Quantity :
100 uL
Price :
US 460.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C
Description :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Immunogen :
A synthesized peptide derived from human CASP3(Accession P42574), corresponding to amino acid residues C163-M182.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000
Aliases :
A830040C14Rik; AC-3; Apopain; Casp3; CASP-3; caspase 3; Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis related cysteine protease; Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease); caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; Caspase-3; Caspase-3 subunit p12; Caspase-3 subunit p17; CC3; Cpp32; CPP-32; CPP32B; CPP32beta; cysteine protease CPP32; IRP; Lice; mldy; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; Yama; yama protein
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA