TERT Polyclonal Antibody | Invitrogen PA5-11446 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TERT Polyclonal Antibody

catalog :

PA5-11446

quantity :

400 uL

price :

US 470.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Reference
Gonz xe1 lez Giraldo Y, Garz xf3 n Benitez A, Forero D, Barreto G. TERT inhibition leads to reduction of IL-6 expression induced by palmitic acid and interferes with the protective effects of tibolone in an astrocytic cell model. J Neuroendocrinol. 2019;31:e12768 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TERT Polyclonal Antibody

Catalog # :

PA5-11446

Quantity :

400 uL

Price :

US 470.00

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation, Size-exclusion - Dialysis

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Western Blot: 1:2,000

Species :

Human

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

Immunogen :

KLH conjugated synthetic peptide between 627-656 amino acids from the central region of human TERT

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:10-1:50, Immunocytochemistry: 1:10-1:50, Western Blot: 1:2,000

Aliases :

CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT