ARPP21 Polyclonal Antibody | Invitrogen PA5-113748 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ARPP21 Polyclonal Antibody

catalog :

PA5-113748

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

ARPP21 Polyclonal Antibody

Catalog # :

PA5-113748

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 0.2-1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Immunogen :

Synthetic peptide directed towards the N terminal region of human ARPP-21 (aa 74-123).

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.2-1 ug/mL

Aliases :

0710001E13Rik; AI853636; ARPP21; Arpp-21; cAMP regulated phosphoprotein 21; cAMP regulated phosphoprotein 21kDa; cAMP-regulated phosphoprotein (21 kDa); cAMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein, 21; cyclic AMP-regulated phosphoprotein, 21 kD; D9Bwg1012e; Ppp1r1c; Ppp1r1cl; protein phosphatase 1, regulatory (inhibitory subunit 1C); protein phosphatase 1, regulatory (inhibitory) subunit 1C; protein phosphatase 1, regulatory subunit 1C; R3H domain containing 3; R3HDM3; RCS; Regulator of calmodulin signaling; RGD1307208; RGD1307215; TARPP; thymocyte ARPP; thymocyte cAMP-regulated phosphoprotein