GLTSCR2 Polyclonal Antibody | Invitrogen PA5-113468 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GLTSCR2 Polyclonal Antibody

catalog :

PA5-113468

quantity :

100 ug

price :

US 424.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

GLTSCR2 Polyclonal Antibody

Catalog # :

PA5-113468

Quantity :

100 ug

Price :

US 424.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:500-1:1,000, Western Blot: 1:500-1:5,000

Species :

Human, Rat

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription. Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation. It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation. Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apoptosis by positively regulating the stability of PTEN, thereby antagonizing the PI3K-AKT/PKB signaling pathway. May also inhibit cell proliferation and increase apoptosis through its interaction with NF2. May negatively regulate NPM1 by regulating its nucleoplasmic localization, oligomerization and ubiquitin-mediated proteasomal degradation. Thereby, may prevent NPM1 interaction with MYC and negatively regulate transcription mediated by the MYC-NPM1 complex. May also regulate cellular aerobic respiration. In the cellular response to viral infection, may play a role in the attenuation of interferon-beta through the inhibition of DDX58/RIG-1.

Immunogen :

Recombinant Human Ribosome biogenesis protein NOP53 protein (227-405AA)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Paraffin): 1:500-1:1,000, Western Blot: 1:500-1:5,000

Aliases :

5330430H08Rik; 9430097C02Rik; AU041936; AW536441; glioma tumor suppressor candidate region gene 2; glioma tumor suppressor candidate region gene 2 protein; GLT; GLTSCR2; LOW QUALITY PROTEIN: glioma tumor suppressor candidate region gene 2 protein; NOP53; NOP53 ribosome biogenesis factor; p60; PICT1; PICT-1; preS1 binding protein; PreS1-binding protein; Protein interacting with carboxyl terminus 1; R74911; Ribosome biogenesis protein NOP53