This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
WISP1 Polyclonal Antibody
catalog :
PA5-112786
quantity :
100 ug
price :
US 424.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
WISP1 Polyclonal Antibody
Catalog # :
PA5-112786
Quantity :
100 ug
Price :
US 424.00
Clonality :
Polyclonal
Purity :
Protein G
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
ELISA: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000-1:5,000
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20 C or -80 C if preferred
Description :
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
Immunogen :
Recombinant Human WNT1-inducible-signaling pathway protein 1 protein (130-251AA)
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000-1:5,000
Aliases :
AW146261; CCN family member 4; Ccn4; CTC-458A3.8; Elm1; ELM-1; WISP1; WISP-1; WISP1c; WISP1i; WISP1tc; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1; Wnt-1 inducible signaling pathway protein 1; Wnt-1-induced secreted protein; WNT1-inducible-signaling pathway protein 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA