PAK3 Polyclonal Antibody | Invitrogen PA5-112638 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PAK3 Polyclonal Antibody

catalog :

PA5-112638

quantity :

100 ug

price :

US 424.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

PAK3 Polyclonal Antibody

Catalog # :

PA5-112638

Quantity :

100 ug

Price :

US 424.00

Clonality :

Polyclonal

Purity :

Protein G

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:500-1:5,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.

Immunogen :

Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:500-1:5,000

Aliases :

2.7.11.1; adriamycin resistance-associated; ARA; beta-PAK; bPAK; CDC42/RAC effector kinase PAK-B; CDKN1A; hPAK3; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 3; p65-PAK; PAK beta; Pak3; Pak-3; PAK3beta; Pak65alpha; Pak65beta; Pakb; Serine/threonine-protein kinase PAK 3; Stk4