This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PMCA4 ATPase Polyclonal Antibody
catalog :
PA5-111763
quantity :
50 µL
price :
US 536.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
product information
Product Type :
Antibody
Product Name :
PMCA4 ATPase Polyclonal Antibody
Catalog # :
PA5-111763
Quantity :
50 µL
Price :
US 536.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Rat
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 1:300, Western Blot: 1:200
Species :
Rat
Isotype :
IgG
Storage :
-20°C
Description :
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).
Immunogen :
Peptide corresponding to amino acid residues 601-617 of rat PMCA4 (2nd intracellular loop)
Format :
Lyophilized
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): 1:300, Western Blot: 1:200
Aliases :
ATP2B2; ATP2B4; ATPase plasma membrane Ca2+ transporting 4; ATPase, Ca++ transporting, plasma membrane 4; ATPase, Ca++ transporting, plasma membrane 4 ATP synthase, H+ transporting, mitochondrial F1; ATPase, Ca++ transporting, plasma membrane 4 tv2; matrix-remodeling-associated protein 1; MXRA1; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium ATPase 4; plasma membrane calcium ATPase 4 variant b; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 4; plasma membrane calcium-pumping ATP-ase; plasma membrane calcium-transporting ATPase 4; PMCA4; PMCA4b; PMCA4x; sarcolemmal calcium pump
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA