Shootin1 Polyclonal Antibody | Invitrogen PA5-111091 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Shootin1 Polyclonal Antibody

catalog :

PA5-111091

quantity :

100 uL

price :

US 474.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Shootin1 Polyclonal Antibody

Catalog # :

PA5-111091

Quantity :

100 uL

Price :

US 474.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunocytochemistry: 0.25-2 ug/mL, Western Blot: 0.04-0.4 ug/mL

Species :

Human, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

SHTN1 is a protein coding gene involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Immunogen :

Recombinant Protein corresonding to Human Shootin1. Recombinant protein control fragment (Product # RP-97202 ).

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.25-2 ug/mL, Western Blot: 0.04-0.4 ug/mL

Aliases :

4930506M07Rik; Kiaa1598; mKIAA1598; RGD1311558; RIKEN cDNA 4930506M07 gene; shootin 1; Shootin1; shootin-1; shot1; Shtn1; similar to 4930506M07Rik protein