Phospho-ROR1 (Tyr786) Polyclonal Antibody | Invitrogen PA5-106150 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-ROR1 (Tyr786) Polyclonal Antibody

catalog :

PA5-106150

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-ROR1 (Tyr786) Polyclonal Antibody

Catalog # :

PA5-106150

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

sequential chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:1,000-1:3,000

Species :

Human

Isotype :

IgG

Storage :

-20 C

Description :

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated, surface protein predominantly expressed during embryogenesis, where it is involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. Virtually absent from normal pediatric and adult tissues, with the exception of low-level expression in a subset of immature b cell precursors known as hematogones and adipocytes, ROR1 is notably overexpressed, and considered a survival factor, in a number of B lymphoid and epithelial malignancies: including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, lung adenocarcinoma. First identified during PCR-based cloning of a human neuroblastoma cell line in search of tyrosine kinases similar to tropomyosin-receptor-kinase (Trk) neurotropic receptors, ROR1, along with the related receptor tyrosine kinase (RTK) ROR2, was catalogued as an 'orphan' receptor due to the fact its related ligand remained elusive. Wnt-5a has since been suggested as a candidate ligand for ROR1, and ROR1 has been implicated to function as a pseudokinase, promoting proliferation and resistance to apoptosis in cancer cells through interaction with Wnt-5a, and TCL1-co-activation of AKT. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin (Ig)-like, Frizzled, and Kringle domains, as well as an intracellular region containing a tyrosine kinase domain.

Immunogen :

A synthesized peptide derived from human ROR1(Accession Q01973), corresponding to amino acid residues around phosphorylated Tyr786.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000-1:3,000

Aliases :

2810404D04Rik; dJ537F10.1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; mRor1; neurotrophic tyrosine kinase, receptor related 1; neurotrophic tyrosine kinase, receptor-related 1; Ntrkr1; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; RGD1559469; ROR1; T-ROR1; tyrosine-protein kinase transmembrane receptor ROR1