Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody | Invitrogen PA5-105895 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody

catalog :

PA5-105895

quantity :

100 uL

price :

US 440.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Phospho-LATS1/LATS2 (Ser909, Ser872) Polyclonal Antibody

Catalog # :

PA5-105895

Quantity :

100 uL

Price :

US 440.00

Clonality :

Polyclonal

Purity :

sequential chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Immunogen :

A synthesized peptide derived from human LATS1(Accession O95835), corresponding to amino acid residues around phosphorylated Ser872.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Aliases :

4932411G09Rik; AV277261; AW208599; AW228608; h-warts; kinase phosphorylated during mitosis protein; KPM; large tumor suppressor; large tumor suppressor 2; large tumor suppressor homolog 1; Large tumor suppressor homolog 2; large tumor suppressor kinase 1; large tumor suppressor kinase 2; large tumor suppressor, homolog 2; large tumor supressor, homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS (large tumor suppressor, Drosophila) homolog 2; LATS, large tumor suppressor, homolog 1; LATS, large tumor suppressor, homolog 2; lats1; Lats2; RGD1564085; serine/threonine kinase KPM; serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS1; serine/threonine-protein kinase LATS2; WARTS; WARTS protein kinase; warts-like kinase; wts