Phospho-BRSK2 (Thr260) Polyclonal Antibody | Invitrogen PA5-105868 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-BRSK2 (Thr260) Polyclonal Antibody

catalog :

PA5-105868

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-BRSK2 (Thr260) Polyclonal Antibody

Catalog # :

PA5-105868

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

sequential chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Western Blot: 1:1,000-1:3,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C

Description :

BRSK2 is a brain-selective serine/threonine kinase 2 that is mainly expressed in the brain, with weaker expression in testis and pancreas. BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C and CDC25B in an in vitro assay. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhanced endogenous BRSK2 kinase activity in a caffeine-sensitive manner and caused translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 induces G2/M arrest in HeLa cells. Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest. BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.

Immunogen :

A synthesized peptide derived from human BRSK2(Accession Q8IWQ3), corresponding to amino acid residues around phosphorylated Thr260.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000-1:3,000

Aliases :

4833424K13Rik; BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; brain serine/threonine kinase 2; brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; BRSK2; C11orf7; HUSSY-12; Kiaa4256; PEN11B; protein kinase SAD1B; SAD1; SAD1B; Sada; SAD-A; serine/threonine-protein kinase 29; Serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A; STK29; testicular tissue protein Li 30