This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-GRK1 (Ser21) Polyclonal Antibody
catalog :
PA5-105659
quantity :
100 uL
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
product information
Product Type :
Antibody
Product Name :
Phospho-GRK1 (Ser21) Polyclonal Antibody
Catalog # :
PA5-105659
Quantity :
100 uL
Price :
US 464.00
Clonality :
Polyclonal
Purity :
sequential chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Western Blot: 1:500-1:2,000
Species :
Human, Mouse, Non-human primate, Rat
Isotype :
IgG
Storage :
-20 C
Description :
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases. GRK1 mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin which leads to its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). GRK1 can be phosphorylated by PKA and this reduces the ability of GRK1 to phosphorylate rhodopsin in vitro. It is speculated that phosphorylation of GRK1 by PKA in vivo occurs in the dark when cAMP levels in photoreceptor cells are elevated.
Immunogen :
A synthesized peptide derived from human GRK1(Accession Q15835), corresponding to amino acid residues around phosphorylated Ser21.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:500-1:2,000
Aliases :
G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; GPRK1; G-protein coupled receptor kinase 1; G-protein receptor kinase 1; GRK 1a/b; GRK1; GRK1a; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; RK
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA