This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
TM2D1 Polyclonal Antibody
catalog :
PA5-104180
quantity :
100 uL
price :
US 464.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
product information
Product Type :
Antibody
Product Name :
TM2D1 Polyclonal Antibody
Catalog # :
PA5-104180
Quantity :
100 uL
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Western Blot: 1:1,000-1:3,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C
Description :
Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the -Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer's disease. Proteolytic cleavage of APP leads to the formation of the Amyloid /A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer's patients. BBP (Beta-amyloid-binding protein), also known as TM2D1 (TM2 domain-containing protein 1), is a 207 amino acid multi-pass membrane protein containing a G protein-coupling module that allows for interaction with the -amyloid peptide of APP. In cell culture, expression of BBP induces caspase-dependent vulnerability to -amyloid peptide toxicity, suggesting that it is a target of -amyloid and may be involved in the molecular pathophysiology of Alzheimer's disease.
Immunogen :
A synthesized peptide derived from human TM2D1(Accession Q9BX74), corresponding to amino acid residues S39-T89.
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1:1,000-1:3,000
Aliases :
2310026L18Rik; AA990549; Amyloid-beta-binding protein; Bbp; beta-amyloid binding protein; beta-amyloid-binding protein; hBBP; mBBP; TM2 domain containing 1; TM2 domain-containing protein 1; Tm2d1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA