Phospho-PERK (Thr982) Polyclonal Antibody | Invitrogen PA5-102853 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PERK (Thr982) Polyclonal Antibody

catalog :

PA5-102853

quantity :

100 uL

price :

US 454.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Guo Z, Yu X, Zhao S, Zhong X, Huang D, Feng R, et al. SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter. Clin Transl Med. 2023;13:e1377 pubmed publisher
Peng W, Zhu T, Xiang G, Ding T, Zhao J, Xiong D, et al. Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model. Diabet Med. 2023;40:e15051 pubmed publisher
Sohn J, Milosević J, Brouse T, Aziz N, Elkhoury J, Wang S, et al. A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. Blood Adv. 2022;6:2557-2577 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-PERK (Thr982) Polyclonal Antibody

Catalog # :

PA5-102853

Quantity :

100 uL

Price :

US 454.00

Clonality :

Polyclonal

Purity :

sequential chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

Immunogen :

A synthesized peptide derived from human EIF2AK3(Accession Q9NZJ5), corresponding to amino acid residues around phosphorylated Thr 982.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:3,000

Aliases :

2.7.11.1; AI427929; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PEK; Perk; PRKR-like endoplasmic reticulum kinase; WRS