IGF2R Polyclonal Antibody | Invitrogen PA3-850 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IGF2R Polyclonal Antibody

catalog :

PA3-850

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunocytochemistry, dot blot

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:100; fig 3	Marquer C, Tian H, Yi J, Bastien J, Dall Armi C, Yang Klingler Y, et al. Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016;7:11919 pubmed publisher
	Bilekova S, Garcia Colomer B, Cebrian Serrano A, Schirge S, Krey K, Sterr M, et al. Inceptor facilitates acrosomal vesicle formation in spermatids and is required for male fertility. Front Cell Dev Biol. 2023;11:1240039 pubmed publisher
	Larocque G, La Borde P, Clarke N, Carter N, Royle S. Tumor protein D54 defines a new class of intracellular transport vesicles. J Cell Biol. 2020;219: pubmed publisher
	Faris R, Merling M, Andersen S, Dooley C, Hackstadt T, Weber M. Chlamydia trachomatis CT229 Subverts Rab GTPase-Dependent CCV Trafficking Pathways to Promote Chlamydial Infection. Cell Rep. 2019;26:3380-3390.e5 pubmed publisher

product information

Product Type :

Antibody

Product Name :

IGF2R Polyclonal Antibody

Catalog # :

PA3-850

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse, Non-human primate

Applications :

Dot Blot: 1:1,000, Immunocytochemistry: 1:50-1:500, Western Blot: 1:2,000-1:3,000

Species :

Bovine, Human, Mouse, Non-human primate

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of approximately 300 kDa cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and approximately 10 % at cell surface. In addition to its man6P binding activity, the MPR contains a separate binding site for the type II insulin-like growth factor and is capable of binding both man6P and IGF-II simultaneously. An approximately 240 kDa soluble, truncated form, representing the extracellular domain of the protein, has also been found circulating in serum and is capable of binding both ligands.

Immunogen :

300 kDa cation-independent receptor purified from adult bovine liver tissue.

Format :

Liquid

Applications w/Dilutions :

Dot Blot: 1:1,000, Immunocytochemistry: 1:50-1:500, Western Blot: 1:2,000-1:3,000

Aliases :

300 kDa mannose 6-phosphate receptor; AI661837; cation-independent mannose 6-phosphate receptor; cation-independent mannose 6-phosphate receptor protein; cation-independent mannose-6-phosphate receptor; cation-independent MPR; CD222; CI Man-6-P receptor; CI-M6PR; CIMPR; CI-MPR; Igf2r; IGF-II receptor; IGF-II/CI-MPR; Igfr2; insulin like growth factor 2 receptor; insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; M6P; M6P/IGF2 receptor; M6P/IGF2R; M6PR; M6P-R; mannose-6-phosphate receptor, cation independent; mannose-6-phosphate/insulin-like growth factor II receptor; MPR 300; MPR1; MPR300; MPRI; similar to mannose-6-phosphate/insulin-like growth factor II receptor

more info or order :

Invitrogen product webpage