IFIT1 Polyclonal Antibody | Invitrogen PA3-846 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IFIT1 Polyclonal Antibody

catalog :

PA3-846

quantity :

100 uL

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

citations: 2

Reference
Xiong X, Wang Q, Wang S, Zhang J, Liu T, Guo L, et al. Mapping the molecular signatures of diet-induced NASH and its regulation by the hepatokine Tsukushi. Mol Metab. 2019;20:128-137 pubmed publisher
Lane W, Dunn M, Gardner C, Lam L, Watson A, Hartman A, et al. The Efficacy of the Interferon Alpha/Beta Response versus Arboviruses Is Temperature Dependent. MBio. 2018;9: pubmed publisher

product information

Product Type :

Antibody

Product Name :

IFIT1 Polyclonal Antibody

Catalog # :

PA3-846

Quantity :

100 uL

Price :

US 451.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Mouse

Applications :

Western Blot: Assay-dependent

Species :

Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.

Immunogen :

aa 217-233 of mouse IFIT1

Format :

Liquid

Applications w/Dilutions :

Western Blot: Assay-dependent

Aliases :

C56; G10P1; Garg16; GARG-16; glucocorticoid-attenuated response gene 16 product; glucocorticoid-attenuated response gene 16 protein; Ifi56; IFI-56; IFI-56K; IFIT1; IFIT-1; IFNAI1; interferon induced protein with tetratricopeptide repeats 1; interferon, alpha-inducible protein (MW 56kD); interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1; interferon-induced protein with tetratricopeptide repeats 1-like protein; interferon-inducible mRNA 561; Isg56; P56; RNM561