Glucocorticoid Receptor beta Polyclonal Antibody | Invitrogen PA3-514 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Glucocorticoid Receptor beta Polyclonal Antibody

catalog :

PA3-514

quantity :

50 uL

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2	Bergström I, Lundberg A, Jonsson S, Särndahl E, Ernerudh J, Jonasson L. Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity. PLoS ONE. 2017;12:e0174177 pubmed publisher
immunocytochemistry; human; 1:500; fig 2	Nagy Z, Acs B, Butz H, Feldman K, Marta A, Szabó P, et al. Overexpression of GRÃŸ in colonic mucosal cell line partly reflects altered gene expression in colonic mucosa of patients with inflammatory bowel disease. J Steroid Biochem Mol Biol. 2016;155:76-84 pubmed publisher
	Jiang Y, Liu B, Bao X, Zhou P, Li J. TNF-α Regulates the Glucocorticoid Receptor Alpha Expression in Human Nasal Epithelial Cells Via p65-NF-κb and p38-MAPK Signaling Pathways. Iran J Biotechnol. 2023;21:e3117 pubmed publisher
	Patel G, Liu Y, Millar J, Clark A. Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice. Sci Rep. 2018;8:862 pubmed publisher
	Molina M, Guerrero J, Cidlowski J, Gatica H, Goecke A. LPS regulates the expression of glucocorticoid receptor ? and ? isoforms and induces a selective glucocorticoid resistance in vitro. J Inflamm (Lond). 2017;14:22 pubmed publisher
	Shang H, Meng W, Sloboda D, Li S, Ehrlich L, Plagemann A, et al. Effects of maternal dexamethasone treatment early in pregnancy on glucocorticoid receptors in the ovine placenta. Reprod Sci. 2015;22:534-44 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Glucocorticoid Receptor beta Polyclonal Antibody

Catalog # :

PA3-514

Quantity :

50 uL

Price :

US 451.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:1,500, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Glucocorticoids are a family of steroids necessary for the regulation of energy metabolism, and the immune and inflammatory responses. These compounds exert their effect through their interaction with the glucocorticoid receptor (GR) and that complex's subsequent association with DNA. All normal mammalian tissues examined to date have been shown to contain GR. The human GR exists in two forms, alpha and beta, which are thought to be the result of alternative splicing of a single gene. Sequence analysis indicates that the alpha and beta forms of human GR are 777 and 742 amino acids long, respectively. They are identical up to residue 727, after which they diverge. After ligand binding, the 94 kDa GR alpha isoform has been observed to translocate from the cytoplasm to the nucleus where it regulates gene expression. In contrast, the 90 kDa GR beta isoform does not appear to bind either glucocorticoid agonists or antagonists, and has been localized predominantly in the nucleus independent of hormone treatment in some human cell lines. Studies suggest that human GR beta might function as a dominant negative inhibitor of GR alpha activity.

Immunogen :

Synthetic Peptide: N(728) V M W L K P E S T S H T L I(742) C

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,500, Immunoprecipitation: Assay-dependent, Western Blot: 1:500

Aliases :

GCCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; GR; GR Beta; GRL; NR3C1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

more info or order :

Invitrogen product webpage