This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CXCR4 Polyclonal Antibody
catalog :
PA3-305
quantity :
100 uL
price :
US 451.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 15
Reference
Kumar S, De Leon E, Granados J, Whitworth D, Vandeberg J. Monodelphis domestica Induced Pluripotent Stem Cells Reveal Metatherian Pluripotency Architecture. Int J Mol Sci. 2022;23: pubmed publisher
Zhang L, Mamillapalli R, Habata S, McAdow M, Taylor H. Myometrial-derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice. J Cell Mol Med. 2022;26:2566-2578 pubmed publisher
Xing B, Yang L, Cui Y. Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation. Cancer Biomark. 2022;33:317-330 pubmed publisher
Janjetovic S, Lohneis P, Nogai A, Balci D, Rasche L, J xe4 hne D, et al. Clinical and Biological Characteristics of Medullary and Extramedullary Plasma Cell Dyscrasias. Biology (Basel). 2021;10: pubmed publisher
Tal A, Tal R, Kliman H, Taylor H. Loss of Cxcr4 in Endometriosis Reduces Proliferation and Lesion Number while Increasing Intraepithelial Lymphocyte Infiltration. Am J Pathol. 2021;191:1292-1302 pubmed publisher
Koo H, Yoon M, Hong S, Ahn J, Cha H, Lee D, et al. CXCL12 enhances pregnancy outcome via improvement of endometrial receptivity in mice. Sci Rep. 2021;11:7397 pubmed publisher
Hervás Salcedo R, Fernández García M, Hernando Rodriguez M, Quintana Bustamante O, Segovia J, Alvarez Silva M, et al. Enhanced anti-inflammatory effects of mesenchymal stromal cells mediated by the transient ectopic expression of CXCR4 and IL10. Stem Cell Res Ther. 2021;12:124 pubmed publisher
Verheijen N, Suttorp C, van Rheden R, Regan R, Helmich M, Kuijpers Jagtman A, et al. CXCL12-CXCR4 Interplay Facilitates Palatal Osteogenesis in Mice. Front Cell Dev Biol. 2020;8:771 pubmed publisher
Nagai K, Ideguchi H, Kajikawa T, Li X, Chavakis T, Cheng J, et al. An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes T regulatory cell recruitment and enhances alveolar bone regeneration during resolution of experimental periodontitis. FASEB J. 2020;34:13726-13740 pubmed publisher
Rivera C, Crisóstomo M, Peña C, González Díaz P, González Arriagada W. Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets. Sci Rep. 2020;10:5454 pubmed publisher
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, et al. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. J Cell Mol Med. 2020;24:2464-2474 pubmed publisher
Nicastro M, Vescovini R, Maritati F, Palmisano A, Urban M, Incerti M, et al. Fibrocytes in Chronic Periaortitis: A Novel Mechanism Linking Inflammation and Fibrosis. Arthritis Rheumatol. 2019;71:1913-1922 pubmed publisher
Domingueti C, Janini J, Paranaíba L, Lozano Burgos C, Olivero P, González Arriagada W. Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth. Med Oral Patol Oral Cir Bucal. 2019;24:e354-e363 pubmed publisher
Benedicto A, Romayor I, Arteta B. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Oncol Rep. 2018;39:2022-2030 pubmed publisher
Séhédic D, Chourpa I, Tétaud C, Griveau A, Loussouarn C, Avril S, et al. Locoregional Confinement and Major Clinical Benefit of 188Re-Loaded CXCR4-Targeted Nanocarriers in an Orthotopic Human to Mouse Model of Glioblastoma. Theranostics. 2017;7:4517-4536 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CXCR4 Polyclonal Antibody
Catalog # :
PA3-305
Quantity :
100 uL
Price :
US 451.00
Clonality :
Polyclonal
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Flow Cytometry: 1:1,000-1:5,000, Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Western Blot: 1:1,000-1:5,000
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.
Immunogen :
Synthetic peptide corresponding to residues K(338) G K R G G H S S V S T E S E S S S F H S S (359) of human CXCR4 receptor protein.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:1,000-1:5,000, Immunocytochemistry: 1:1,000-1:5,000, Immunohistochemistry (Paraffin): 1:1,000-1:5,000, Western Blot: 1:1,000-1:5,000
Aliases :
b2b220Clo; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD antigen CD184; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor; chemokine receptor (LCR1); chemokine receptor 4; chemokine receptor CXCR4; Cmkar4; CXC; CXC chemokine receptor; C-X-C chemokine receptor type 4; CXC motif chemokine; C-X-C motif chemokine receptor 4; CXCR4; CXC-R4; CXCR-4; D2S201E; FB22; Fusin; HM89; HSY3RR; HUMSTR; LAP3; LAP-3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; PB-CKR; PBSF/SDF-1; pre-B-cell-derived chemokine receptor; SDF-1 receptor; Sdf1r; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM; WHIMS
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA