CADM1 Polyclonal Antibody | Invitrogen PA3-16744 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CADM1 Polyclonal Antibody

catalog :

PA3-16744

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; loading ...; fig 1e	Fowler D, Peters J, Williams C, Washbourne P. Redundant Postsynaptic Functions of SynCAMs 1-3 during Synapse Formation. Front Mol Neurosci. 2017;10:24 pubmed publisher
western blot; rat; loading ...; fig 3d	Rademacher N, Schmerl B, Lardong J, Wahl M, Shoichet S. MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density. Sci Rep. 2016;6:35283 pubmed publisher
	Kosibaty Z, Brustugun O, Zwicky Eide I, Tsakonas G, Grundberg O, De Petris L, et al. Ras-Related Protein Rab-32 and Thrombospondin 1 Confer Resistance to the EGFR Tyrosine Kinase Inhibitor Osimertinib by Activating Focal Adhesion Kinase in Non-Small Cell Lung Cancer. Cancers (Basel). 2022;14: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CADM1 Polyclonal Antibody

Catalog # :

PA3-16744

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunocytochemistry: 1:2,000, Western Blot: 1:1,000

Species :

Human, Rat

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Immunogen :

A synthetic peptide corresponding to the C-terminal region of the rat protein.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:2,000, Western Blot: 1:1,000

Aliases :

2900073G06Rik; 3100001I08Rik; AI987920; Bl2; cadm1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; Igsf4; Igsf4a; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; immunosuperfamily protein Bl2; Necl2; NECL-2; nectin-like 2; nectin-like protein 2; RA175; RA175A; RA175B; RA175C; RA175N; secretory isoform of TSLC1; sgigsf; Spermatogenic immunoglobulin superfamily; ST17; sTSLC-1; Synaptic cell adhesion molecule; SynCAM; SynCam1; truncated CADM1 protein; TSLC1; TSLC-1; TSLC1/Nectin-like 2/IGSF4; tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog

more info or order :

Invitrogen product webpage