Lubricin Polyclonal Antibody | Invitrogen PA3-118 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Lubricin Polyclonal Antibody

catalog :

PA3-118

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 5

Reference
Menon N, Goyal R, Lema C, Woods P, Tanguay A, Morin A, et al. Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation. Exp Eye Res. 2021;208:108628 pubmed publisher
Peal B, Gagliardi R, Su J, Fortier L, Delco M, Nixon A, et al. Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury, and full-thickness cartilage defect models. J Orthop Res. 2020;38:1826-1835 pubmed publisher
Feeney E, Peal B, Inglis J, Su J, Nixon A, Bonassar L, et al. Temporal changes in synovial fluid composition and elastoviscous lubrication in the equine carpal fracture model. J Orthop Res. 2019;37:1071-1079 pubmed publisher
Chavez R, Sohn P, Serra R. Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice. PLoS ONE. 2019;14:e0210601 pubmed publisher
Flowers S, Zieba A, Örnros J, Jin C, Rolfson O, Björkman L, et al. Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface. Sci Rep. 2017;7:13149 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Lubricin Polyclonal Antibody

Catalog # :

PA3-118

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 2 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Lubricin is a glycoprotein encoded by the PRG4 gene. It has been identified as a component of joint lubrication and synovial homeostasis by reducing friction in joints and preventing synovial cell overgrowth. It is a large, water soluble molecule that acts as a carrier for insoluble surface-active phospholipid (SAPL). Depletion of lubricin function has been associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), an arthritic-like autosomal recessive disorder.

Immunogen :

Synthetic peptide corresponding to residues C L(1356) P N I R K Q P D G Y D Y Y A F S K D Q(1374) of human Lubricin.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 2 ug/mL

Aliases :

articular superficial zone protein; CACP; DOL54; HAPO; hemangiopoietin; JCAP; Lubricin; megakaryocyte stimulating factor; megakaryocyte-stimulating factor; MSF; PRG4; proteoglycan 3; proteoglycan 4; proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); Proteoglycan 4 C-terminal part; Proteoglycan-4; Superficial zone proteoglycan; SZP