CYP2C11 Polyclonal Antibody | Invitrogen PA3-034 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CYP2C11 Polyclonal Antibody

catalog :

PA3-034

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Reference
Zhou H, Yang L, Wang C, Li Z, Ouyang Z, Shan M, et al. CYP2D1 Gene Knockout Reduces the Metabolism and Efficacy of Venlafaxine in Rats. Drug Metab Dispos. 2019;47:1425-1432 pubmed publisher
Wei Y, Yang L, Zhang X, Sui D, Wang C, Wang K, et al. Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method. Drug Metab Dispos. 2018;46:525-531 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CYP2C11 Polyclonal Antibody

Catalog # :

PA3-034

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Host :

Rabbit

Reactivity :

Feline, Human, Rat

Applications :

Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:1,500

Species :

Feline, Human, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The cytochrome P450 (P450) family of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as NADPH and P450 reductase. There are over 200 cDNA’s which encode P450 protein. Epoxygenases are those P450 proteins which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450 proteins which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). EET’s, which exhibit vasodilation activity, are formed when an epoxide group is inserted between the unsaturated carbons of AA in positions 5,6; 8,9; 11,12; 14,15. EET’s are produced in cerebral cortical tissue, coronary arteries and vascular endothelium. EET’s are converted from AA by the 2C11 family of P450’s whose expression is induced by testosterone and is therefore not generally found in females.

Immunogen :

Synthetic peptides corresponding to residues D(49) I G Q S I K K F S K V(60) and Q(491) R A D S L S S H L(500) of rat Cytochrome P450 2C11.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Frozen): 1:100, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:1,500

Aliases :

CYP; Cyp2c; Cyp2c11; Cyp2c-11; CYP2CII; CYPIIC11; cytochrome P450 2C11; Cytochrome P-450(M-1); cytochrome P450, 2c29; cytochrome P450, subfamily 2, polypeptide 11; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase); cytochrome P450H; cytochrome P450-UT-2; Cytochrome P450-UT-A; P450; P-450(M-1); P450H; P450-UT-A; UT-2