PSMD1 Polyclonal Antibody | Invitrogen PA1-973 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSMD1 Polyclonal Antibody

catalog :

PA1-973

quantity :

100 ug

price :

US 491.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry

citations: 2

Reference
Chadchankar J, Korboukh V, Conway L, Wobst H, Walker C, Doig P, et al. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. PLoS ONE. 2019;14:e0225145 pubmed publisher
Patil H, Yoon D, Bhowmick R, Cai Y, Cho K, Ferreira P. Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I . Small Gtpases. 2019;10:146-161 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PSMD1 Polyclonal Antibody

Catalog # :

PA1-973

Quantity :

100 ug

Price :

US 491.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, Human, Mouse, Non-human primate, Rat

Applications :

Immunohistochemistry: 15 ug/mL, Western Blot: 0.5-2 ug/mL

Species :

Bovine, Human, Mouse, Non-human primate, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

Immunogen :

Synthetic Peptide: A(929) A H G P K I E E E E Q E P E P P E P F E Y I D D(953)

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: 15 ug/mL, Western Blot: 0.5-2 ug/mL

Aliases :

2410026J11Rik; 26S proteasome non-ATPase regulatory subunit 1; 26S proteasome p112 subunit; 26S proteasome regulatory subunit RPN2; 26S proteasome regulatory subunit S1; 26S proteasome subunit p112; 26S proteasome, subunit p112; MGC133040; MGC133041; P112; proteasome (prosome, macropain) 26S subunit, non-ATPase, 1; proteasome 26S non-ATPase subunit 1; proteasome 26S subunit, non-ATPase 1; Psmd1; Rpn2; S1