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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
VDAC Polyclonal Antibody
catalog :
PA1-954A
quantity :
100 ug
price :
US 465.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 32
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig s6d
Petkevicius K, Palmgren H, Glover M, Ahnmark A, Andr xe9 asson A, Madeyski Bengtson K, et al. TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis. Nat Commun. 2022;13:6020 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 9f
Giridharan V, Collodel A, Generoso J, Scaini G, Wassather R, Selvaraj S, et al. Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study. J Neuroinflammation. 2020;17:5 pubmed publisher
  • western blot; mouse; 1:1000; fig 1a
Pereira R, Tadinada S, Zasadny F, Oliveira K, Pires K, Olvera A, et al. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J. 2017;36:2126-2145 pubmed publisher
  • western blot; mouse; fig 1d
D Andrea A, Gritti I, Nicoli P, Giorgio M, Doni M, Conti A, et al. The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas. Oncotarget. 2016;7:72415-72430 pubmed publisher
  • western blot; mouse; 1:1000; fig S7
Basisty N, Dai D, Gagnidze A, Gitari L, Fredrickson J, Maina Y, et al. Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?. Aging Cell. 2016;15:634-45 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:400; fig 6
Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez Marin A, et al. Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. Hum Mol Genet. 2016;25:1792-802 pubmed publisher
  • western blot; rat; fig 3
Visavadiya N, Patel S, VanRooyen J, Sullivan P, Rabchevsky A. Cellular and subcellular oxidative stress parameters following severe spinal cord injury. Redox Biol. 2016;8:59-67 pubmed publisher
Needs H, Wilkinson K, Henley J, Collinson I. Aggregation-prone Tau impairs mitochondrial import, which affects organelle morphology and neuronal complexity. J Cell Sci. 2023;136: pubmed publisher
Tramutola A, Lanzillotta S, Aceto G, Pagnotta S, Ruffolo G, Cifelli P, et al. Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome. Antioxidants (Basel). 2023;12: pubmed publisher
Brontesi L, Imberdis T, Ramalingam N, Dettmer U. The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly. J Neurochem. 2023;165:246-258 pubmed publisher
Pol xe1 chov xe1 E, Bach K, Heuten E, Stanchev S, Tich xe1 A, Lampe P, et al. Chemical Blockage of the Mitochondrial Rhomboid Protease PARL by Novel Ketoamide Inhibitors Reveals Its Role in PINK1/Parkin-Dependent Mitophagy. J Med Chem. 2023;66:251-265 pubmed publisher
Singh R, Croatt A, Ackerman A, Grande J, Trushina E, Salisbury J, et al. Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury. Kidney360. 2022;3:1672-1682 pubmed publisher
Yu H, Alruwaili N, Kelly M, Zhang B, Liu A, Wang Y, et al. Endothelin-1 depletion of cartilage oligomeric matrix protein modulates pulmonary artery superoxide and iron metabolism-associated mitochondrial heme biosynthesis. Am J Physiol Lung Cell Mol Physiol. 2022;323:L400-L409 pubmed publisher
Hackett P, Jia X, Li L, Ward D. Posttranslational regulation of mitochondrial frataxin and identification of compounds that increase frataxin levels in Friedreich's ataxia. J Biol Chem. 2022;298:101982 pubmed publisher
Choi J, Kwon H, Seoh J, Han P. Hyperoxygenation Ameliorates Stress-induced Neuronal and Behavioral Deficits. Exp Neurobiol. 2021;30:415-429 pubmed publisher
Bruno S, Kumar A, Mark Z, Chandrasekaran R, Nakada E, Chamberlain N, et al. DRP1-Mediated Mitochondrial Fission Regulates Lung Epithelial Response to Allergen. Int J Mol Sci. 2021;22: pubmed publisher
Shao J, Shi T, Yu H, Ding Y, Li L, Wang X, et al. Cytosolic GDH1 degradation restricts protein synthesis to sustain tumor cell survival following amino acid deprivation. EMBO J. 2021;40:e107480 pubmed publisher
Pereira R, Marti A, Olvera A, Tadinada S, Bjorkman S, Weatherford E, et al. OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21. elife. 2021;10: pubmed publisher
Ko H, Tsai C, Chiou S, Lai Y, Wang C, Cheng J, et al. The Phosphorylation Status of Drp1-Ser637 by PKA in Mitochondrial Fission Modulates Mitophagy via PINK1/Parkin to Exert Multipolar Spindles Assembly during Mitosis. Biomolecules. 2021;11: pubmed publisher
Carpio M, Means R, Brill A, Sainz A, Ehrlich B, Katz S. BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites. Cell Rep. 2021;34:108827 pubmed publisher
Benedetti L. Optogenetic Tools for Manipulating Protein Subcellular Localization and Intracellular Signaling at Organelle Contact Sites. Curr Protoc. 2021;1:e71 pubmed publisher
Wende A, Schell J, Ha C, Pepin M, Khalimonchuk O, Schwertz H, et al. Maintaining Myocardial Glucose Utilization in Diabetic Cardiomyopathy Accelerates Mitochondrial Dysfunction. Diabetes. 2020;69:2094-2111 pubmed publisher
Yu H, Alruwaili N, Hu B, Kelly M, Zhang B, Sun D, et al. Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia. Am J Physiol Lung Cell Mol Physiol. 2019;317:L569-L577 pubmed publisher
Sloat S, Whitley B, Engelhart E, Hoppins S. Identification of a Mitofusin specificity region that confers unique activities to Mfn1 and Mfn2. Mol Biol Cell. 2019;:mbcE19050291 pubmed publisher
Senese R, Cioffi F, De Matteis R, Petito G, de Lange P, Silvestri E, et al. 3,5 Diiodo-l-Thyronine (T₂) Promotes the Browning of White Adipose Tissue in High-Fat Diet-Induced Overweight Male Rats Housed at Thermoneutrality. Cells. 2019;8: pubmed publisher
Pusec C, DE JESUS A, Khan M, Terry A, Ludvik A, Xu K, et al. Hepatic HKDC1 Expression Contributes to Liver Metabolism. Endocrinology. 2019;160:313-330 pubmed publisher
Gilmore Hall S, Kuo J, Ward J, Zahra R, Morrison R, Perkins G, et al. CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. J Cell Biol. 2019;218:206-219 pubmed publisher
Jeong J, Chang J, Jo Y. Intracellular glycolysis in brown adipose tissue is essential for optogenetically induced nonshivering thermogenesis in mice. Sci Rep. 2018;8:6672 pubmed publisher
Meissner C, Lorenz H, Hehn B, Lemberg M. Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy. Autophagy. 2015;11:1484-98 pubmed publisher
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed publisher
Wang W, Visavadiya N, Pandya J, Nelson P, Sullivan P, Springer J. Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury. Exp Neurol. 2015;265:84-93 pubmed publisher
Jaishy B, Zhang Q, Chung H, Riehle C, Soto J, Jenkins S, et al. Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. J Lipid Res. 2015;56:546-61 pubmed publisher
product information
Product Type :
Antibody
Product Name :
VDAC Polyclonal Antibody
Catalog # :
PA1-954A
Quantity :
100 ug
Price :
US 465.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Non-human primate, Rat
Applications :
Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 2 ug/mL
Species :
Human, Mouse, Non-human primate, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
Immunogen :
Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197)
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:200-1:1,000, Immunohistochemistry (Paraffin): 1:200-1:1,000, Western Blot: 2 ug/mL
Aliases :
AL033343; BR1-VDAC; Brain-derived voltage-dependent anion channel 1; hVDAC1; MGC111064; Mitochondrial outer membrane protein porin 1; Mitochondrial Porin; mVDAC1; mVDAC5; N2441; OMP2; Outer mitochondrial membrane protein porin 1; plasmalemmal porin; POR1; PORIN; Porin 31HL; porin 31HM; porin POR1; PORIN-31-HL; rVDAC1; VD; VDAC; VDAC1; VDAC-1; Vdac5; VDAC-5; voltage dependent anion channel 1; voltage-dependent anion channel 1; voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5; YNL055C; YNL2441C
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA