KCNQ3 Polyclonal Antibody | Invitrogen PA1-930 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KCNQ3 Polyclonal Antibody

catalog :

PA1-930

quantity :

100 ug

price :

US 440.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 2

Reference
Chokvithaya S, Caengprasath N, Buasong A, Jantasuwan S, Santawong K, Leela Adisorn N, et al. Nine patients with KCNQ2-related neonatal seizures and functional studies of two missense variants. Sci Rep. 2023;13:3328 pubmed publisher
Lauritano A, Moutton S, Longobardi E, Tran Mau Them F, Laudati G, Nappi P, et al. A novel homozygous KCNQ3 loss-of-function variant causes non-syndromic intellectual disability and neonatal-onset pharmacodependent epilepsy. Epilepsia Open. 2019;4:464-475 pubmed publisher

product information

Product Type :

Antibody

Product Name :

KCNQ3 Polyclonal Antibody

Catalog # :

PA1-930

Quantity :

100 ug

Price :

US 440.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): 0.5 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Immunogen :

GST fusion protein encoding the first 71 amino acids of rat KCNQ3.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): 0.5 ug/mL

Aliases :

BFNC; BFNC2; EBN2; Kcnq3; KQT-like 3; KV7.3; potassium channel subunit alpha KvLQT3; potassium channel, voltage gated KQT-like subfamily Q, member 3; potassium channel, voltage-gated KQT-like subfamily Q, member 3; potassium channel, voltage-gated, subfamily Q, member 3; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel subfamily Q member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; voltage-gated potassium channel subunit Kv7.3