KCNQ2 Polyclonal Antibody | Invitrogen PA1-929 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KCNQ2 Polyclonal Antibody

catalog :

PA1-929

quantity :

100 ug

price :

US 440.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:200; loading ...; fig 2d immunoprecipitation; rat; loading ...; fig 8 immunocytochemistry; rat; 1:200; loading ...; fig 1b	Pablo J, Pitt G. FGF14 is a regulator of KCNQ2/3 channels. Proc Natl Acad Sci U S A. 2017;114:154-159 pubmed publisher
	Gorlewicz A, Barthet G, Zucca S, Vincent P, Griguoli M, Grosjean N, et al. The Deletion of GluK2 Alters Cholinergic Control of Neuronal Excitability. Cereb Cortex. 2022;32:2907-2923 pubmed publisher
	Nickerson A, Rajendran V. Flupirtine enhances NHE-3-mediated Na+ absorption in rat colon via an ENS-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2021;321:G185-G199 pubmed publisher
	Verneuil J, Brocard C, Trouplin V, Villard L, Peyronnet Roux J, Brocard F. The M-current works in tandem with the persistent sodium current to set the speed of locomotion. PLoS Biol. 2020;18:e3000738 pubmed publisher
	Jenkins P, Kim N, Jones S, Tseng W, Svitkina T, Yin H, et al. Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. Proc Natl Acad Sci U S A. 2015;112:957-64 pubmed publisher

product information

Product Type :

Antibody

Product Name :

KCNQ2 Polyclonal Antibody

Catalog # :

PA1-929

Quantity :

100 ug

Price :

US 440.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 0.5 ug/mL, Immunohistochemistry (Frozen): 0.5 ug/mL, Western Blot: Assay-dependent

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.

Immunogen :

GST fusion protein encoding the first 70 amino acids of human KCNQ2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 0.5 ug/mL, Immunohistochemistry (Frozen): 0.5 ug/mL, Western Blot: Assay-dependent

Aliases :

BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT like 2; KQT2; KQT-like 2; KV7.2; KVEBN1; mKQT2.3; mKQT2.4; neuroblastoma-specific potassium channel subunit alpha KvLQT2; Nmf134; potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; potassium channel, voltage-gated KQT-like subfamily Q, member 2; potassium voltage-gated channel KQT-like subfamily member 2.3; potassium voltage-gated channel KQT-like subfamily member 2.4; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel subfamily Q member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; potassium voltage-gated channel, subfamily Q, member 2; voltage-gated potassium channel subunit Kv7.2

more info or order :

Invitrogen product webpage