KChIP3 Polyclonal Antibody | Invitrogen PA1-928 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KChIP3 Polyclonal Antibody

catalog :

PA1-928

quantity :

100 µg

price :

US 400

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

domestic rabbit

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

KChIP3 Polyclonal Antibody

Catalog # :

PA1-928

Quantity :

100 µg

Price :

US 400

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Rabbit

Applications :

Immunocytochemistry: Assay-dependent, Immunofluorescence: Assay-dependent, Immunohistochemistry (Frozen): 1:25

Species :

Rabbit

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis. KChIP3 has activities beyond the modulation of Kv4 currents. It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos. Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator. KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.

Immunogen :

Synthetic Peptide: I(30) K W Q R P R F T R Q A L M R C(45)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunofluorescence: Assay-dependent, Immunohistochemistry (Frozen): 1:25

Aliases :

4933407H12Rik; AI413860; A-type potassium channel modulating protein 3; A-type potassium channel modulatory protein 3; Calsenilin; calsenilin presenilin-binding protein EF hand transcription factor; calsenilin, presenilin binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription fa; calsenilin, presenilin-binding protein, EF hand transcription factor; calsenilin, presenilin-binding protein, EF hand transcription factor-like; Csen; downstream regulatory element-antagonist modulator; DREAM; DRE-antagonist modulator; KChIP3; Kcnip3; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; kv channel-interacting protein 3; LOC100356268; potassium channel interacting protein 3; potassium voltage-gated channel interacting protein 3; R74849; rKChIP3