KCNMB1 Polyclonal Antibody | Invitrogen PA1-924 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

KCNMB1 Polyclonal Antibody

catalog :

PA1-924

quantity :

100 ug

price :

US 490.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig 6b	Cheng J, Mao L, Wen J, Li P, Wang N, Tan X, et al. Different Effects of Hypertension and Age on the Function of Large Conductance Calcium- and Voltage-Activated Potassium Channels in Human Mesentery Artery Smooth Muscle Cells. J Am Heart Assoc. 2016;5: pubmed publisher
	Simakova M, Bisen S, Dopico A, Bukiya A. Statin therapy exacerbates alcohol-induced constriction of cerebral arteries via modulation of ethanol-induced BK channel inhibition in vascular smooth muscle. Biochem Pharmacol. 2017;145:81-93 pubmed publisher

product information

Product Type :

Antibody

Product Name :

KCNMB1 Polyclonal Antibody

Catalog # :

PA1-924

Quantity :

100 ug

Price :

US 490.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:200, Western Blot: 2.0 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Immunogen :

Synthetic Peptide: L(90) Y H T E D T R D Q N Q Q C(103)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:200, Western Blot: 2.0 ug/mL

Aliases :

big potassium channel beta subunit 1; BK channel beta subunit; BK channel beta subunit 1; BK channel subunit beta-1; BKbeta; BKbeta1; calcium-activated potassium channel beta subunit; calcium-activated potassium channel subunit beta; Calcium-activated potassium channel subunit beta-1; calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; hbeta1; hslo-beta; K(VCA)beta; k(VCA)beta-1; Kcnmb1; large conductance Ca2+-activated K+ channel beta 1 subunit; maxi K channel subunit beta-1; MaxiK channel beta-subunit 1; potassium calcium-activated channel subfamily M regulatory beta subunit 1; potassium channel subfamily M regulatory beta subunit 1; potassium large conductance calcium-activated channel, subfamily M, beta member 1; slo-beta; slo-beta-1; slowpoke-beta

more info or order :

Invitrogen product webpage