alpha-ENaC Polyclonal Antibody | Invitrogen PA1-920A product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

alpha-ENaC Polyclonal Antibody

catalog :

PA1-920A

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5a	Cui Y, Ding Y, Chen L, Li Y, Li Y, Nie H. Dexmedetomidine enhances human lung fluid clearance through improving alveolar sodium transport. Fundam Clin Pharmacol. 2017;31:429-437 pubmed publisher
western blot; human; 1:1000; loading ...; fig 3a	Cui Y, Li H, Wu S, Zhao R, Du D, Ding Y, et al. Formaldehyde impairs transepithelial sodium transport. Sci Rep. 2016;6:35857 pubmed publisher
immunohistochemistry; mouse; 1:800; fig 1	Li Q, Kresge C, Bugde A, Lamphere M, Park J, Feranchak A. Regulation of mechanosensitive biliary epithelial transport by the epithelial Na(+) channel. Hepatology. 2016;63:538-49 pubmed publisher
	Wahl A, Takano T, Su S, Warner B, Perez P, Sneyd J, et al. Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype. J Physiol. 2023;601:4539-4556 pubmed publisher
	Su S, Rugis J, Wahl A, Doak S, Li Y, Suresh V, et al. A Mathematical Model of Salivary Gland Duct Cells. Bull Math Biol. 2022;84:84 pubmed publisher
	Chen L, Hou Y, Du D, Cui Y, Nie H, Ding Y. MiR-199a-3p in mouse bone marrow mesenchymal stem cell exosomes increases epithelial sodium channel expression in lung injury. Fundam Clin Pharmacol. 2022;36:1011-1019 pubmed publisher
	Nouri Z, Zhang X, Khakisahneh S, Degen A, Wang D. The microbiota-gut-kidney axis mediates host osmoregulation in a small desert mammal. NPJ Biofilms Microbiomes. 2022;8:16 pubmed publisher
	Xie X, Yu T, Hou Y, Han A, Ding Y, Nie H, et al. Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway. Respir Res. 2021;22:308 pubmed publisher
	Ding Y, Cui Y, Hou Y, Nie H. Bone marrow mesenchymal stem cell-conditioned medium facilitates fluid resolution via miR-214-activating epithelial sodium channels. MedComm (2020). 2020;1:376-385 pubmed publisher
	Yanda M, Cebotaru L. VX-809 mitigates disease in a mouse model of autosomal dominant polycystic kidney disease bearing the R3277C human mutation. FASEB J. 2021;35:e21987 pubmed publisher
	Deng W, He J, Tang X, Li C, Tong J, Qi D, et al. Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Mol Med Rep. 2021;24: pubmed publisher
	Li J, Liu L, Zhou X, Lu X, Liu X, Li G, et al. Melatonin Attenuates Sepsis-Induced Acute Lung Injury Through Improvement of Epithelial Sodium Channel-Mediated Alveolar Fluid Clearance Via Activation of SIRT1/SGK1/Nedd4-2 Signaling Pathway. Front Pharmacol. 2020;11:590652 pubmed publisher
	Zhang H, Ding Y, Hou Y, Liu Y, Zhou Z, Nie H. Bone marrow mesenchymal stem cells derived miRNA-130b enhances epithelial sodium channel by targeting PTEN. Respir Res. 2020;21:329 pubmed publisher
	Nordström C, Danckwardt Lillieström N, Liu W, Rask Andersen H. "Reversed polarization" of Na/K-ATPase-a sign of inverted transport in the human endolymphatic sac: a super-resolution structured illumination microscopy (SR-SIM) study. Cell Tissue Res. 2020;379:445-457 pubmed publisher
	Shik Mun K, Arora K, Huang Y, Yang F, Yarlagadda S, Ramananda Y, et al. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders. Nat Commun. 2019;10:3124 pubmed publisher
	Hou Y, Cui Y, Zhou Z, Liu H, Zhang H, Ding Y, et al. Upregulation of the WNK4 Signaling Pathway Inhibits Epithelial Sodium Channels of Mouse Tracheal Epithelial Cells After Influenza A Infection. Front Pharmacol. 2019;10:12 pubmed publisher
	He M, Liu S, Gallolu Kankanamalage S, Borromeo M, Girard L, Gazdar A, et al. The Epithelial Sodium Channel (?ENaC) Is a Downstream Therapeutic Target of ASCL1 in Pulmonary Neuroendocrine Tumors. Transl Oncol. 2018;11:292-299 pubmed publisher
	Li Y, Chang J, Cui Y, Zhao R, Ding Y, Hou Y, et al. Novel mechanisms for crotonaldehyde-induced lung edema. Oncotarget. 2017;8:83509-83522 pubmed publisher
	Martinez Lemus L, Aroor A, Ramirez Perez F, Jia G, Habibi J, Demarco V, et al. Amiloride Improves Endothelial Function and Reduces Vascular Stiffness in Female Mice Fed a Western Diet. Front Physiol. 2017;8:456 pubmed publisher
	Messaoudi S, He Y, Gutsol A, Wight A, Hébert R, Vilmundarson R, et al. Endothelial Gata5 transcription factor regulates blood pressure. Nat Commun. 2015;6:8835 pubmed publisher
	Wakui H, Uneda K, Tamura K, Ohsawa M, Azushima K, Kobayashi R, et al. Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation. J Am Heart Assoc. 2015;4:e001594 pubmed publisher

product information

Product Type :

Antibody

Product Name :

alpha-ENaC Polyclonal Antibody

Catalog # :

PA1-920A

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 2 ug/mL, Western Blot: 1:100-1:1,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).

Immunogen :

Synthetic peptide corresponding to residues L(20) M K G N K R E E Q G L G P E P A A P Q Q P T(42) C of Human alpha-Enac.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Western Blot: 1:100-1:1,000

Aliases :

alpha ENaC-2; alpha-ENaC; Alpha-NaCH; amiloride-sensitive epithelial sodium channel; amiloride-sensitive epithelial sodium channel alpha subunit; amiloride-sensitive sodium channel subunit alpha; amiloride-sensitive sodium channel subunit alpha 2; BESC2; ENaC; ENaC alpha; ENaCa; ENaCalpha; Epithelial Na(+) channel subunit alpha; epithelial sodium channel alpha subunit; FLJ21883; mENaC; nasal epithelial sodium channel alpha subunit; nonvoltage-gated sodium channel 1 subunit alpha; Renac; SCNEA; SCNN1; Scnn1a; sodium channel epithelial 1 alpha subunit; sodium channel, non voltage gated 1 alpha subunit; sodium channel, nonvoltage-gated 1 alpha; sodium channel, non-voltage-gated 1 alpha subunit; sodium channel, nonvoltage-gated, type I, alpha; sodium channel, nonvoltage-gated, type I, alpha polypeptide

more info or order :

Invitrogen product webpage