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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PMCA2 ATPase Polyclonal Antibody
catalog :
PA1-915
quantity :
100 ug
price :
US 490.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...
  • western blot; human; loading ...; fig 3a
Jeong J, Kim W, Kim L, VanHouten J, Wysolmerski J. HER2 signaling regulates HER2 localization and membrane retention. PLoS ONE. 2017;12:e0174849 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2i
  • immunocytochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 2i
Jeong J, VanHouten J, Kim W, Dann P, Sullivan C, Choi J, et al. The scaffolding protein NHERF1 regulates the stability and activity of the tyrosine kinase HER2. J Biol Chem. 2017;292:6555-6568 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1a
Weatherstone J, Kopp Scheinpflug C, Pilati N, Wang Y, Forsythe I, Rubel E, et al. Maintenance of neuronal size gradient in MNTB requires sound-evoked activity. J Neurophysiol. 2017;117:756-766 pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Pérez Cañamás A, Benvegnù S, Rueda C, Rábano A, Satrústegui J, Ledesma M. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017;22:711-723 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 1
Peters A, Milevskiy M, Lee W, Curry M, Smart C, Saunus J, et al. The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Sci Rep. 2016;6:25505 pubmed publisher
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 1
Jeong J, VanHouten J, Dann P, Kim W, Sullivan C, Yu H, et al. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer. Proc Natl Acad Sci U S A. 2016;113:E282-90 pubmed publisher
Tao Y, Lamas V, Du W, Zhu W, Li Y, Whittaker M, et al. Treatment of monogenic and digenic dominant genetic hearing loss by CRISPR-Cas9 ribonucleoprotein delivery in vivo. Nat Commun. 2023;14:4928 pubmed publisher
Jeong J, Shin J, Li W, Hong J, Lim J, Hwang J, et al. MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells. Cell Rep. 2021;37:110160 pubmed publisher
Martín de Saavedra M, Dos Santos M, Culotta L, Varea O, Spielman B, Parnell E, et al. Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2. Neuron. 2021;: pubmed publisher
Colaco A, Fernández Suárez M, Shepherd D, Gal L, Bibi C, Chuartzman S, et al. Unbiased yeast screens identify cellular pathways affected in Niemann-Pick disease type C. Life Sci Alliance. 2020;3: pubmed publisher
Laezer I, Palma Vera S, Liu F, Frank M, Trakooljul N, Vernunft A, et al. Dynamic profile of EVs in porcine oviductal fluid during the periovulatory period. Reproduction. 2020;159:371-382 pubmed publisher
Sritangos P, Pena Alarcon E, James A, Sultan A, Richardson D, Bruce J. Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer. Cancers (Basel). 2020;12: pubmed publisher
Gao X, Tao Y, Lamas V, Huang M, Yeh W, Pan B, et al. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018;553:217-221 pubmed publisher
Lisek M, Ferenc B, Studzian M, Pulaski L, Guo F, Zylinska L, et al. Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Front Cell Neurosci. 2017;11:181 pubmed publisher
Minich R, Li J, Tempel B. Early growth response protein 1 regulates promoter activity of α-plasma membrane calcium ATPase 2, a major calcium pump in the brain and auditory system. BMC Mol Biol. 2017;18:14 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PMCA2 ATPase Polyclonal Antibody
Catalog # :
PA1-915
Quantity :
100 ug
Price :
US 490.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Porcine, Rat
Applications :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1:20-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000
Species :
Human, Porcine, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
Immunogen :
Synthetic Peptide: T(5) N S D F Y S K N Q R N E S S(19)
Format :
Liquid
Applications w/Dilutions :
ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1:20-1:200, Immunohistochemistry (Paraffin): 1:20-1:200, Western Blot: 1:1,000
Aliases :
Atp2b2; ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase plasma membrane Ca2+ transporting 2; ATPase, Ca++ transporting, plasma membrane 2; D6Abb2e; deaf waddler; dfw; Gena300; jog; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri; wriggle
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA