PMCA1 ATPase Polyclonal Antibody | Invitrogen PA1-914 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PMCA1 ATPase Polyclonal Antibody

catalog :

PA1-914

quantity :

100 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat, pigs

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 1a	Hegedüs L, Garay T, Molnar E, Varga K, Bilecz A, Torok S, et al. The plasma membrane Ca2+ pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells. Int J Cancer. 2017;140:2758-2770 pubmed publisher
	Naffa R, Padányi R, Ignácz A, Hegyi Z, Jezsó B, Tóth S, et al. The Plasma Membrane Ca2+ Pump PMCA4b Regulates Melanoma Cell Migration through Remodeling of the Actin Cytoskeleton. Cancers (Basel). 2021;13: pubmed publisher
	Sritangos P, Pena Alarcon E, James A, Sultan A, Richardson D, Bruce J. Plasma Membrane Ca2+ ATPase Isoform 4 (PMCA4) Has an Important Role in Numerous Hallmarks of Pancreatic Cancer. Cancers (Basel). 2020;12: pubmed publisher
	Lisek M, Ferenc B, Studzian M, Pulaski L, Guo F, Zylinska L, et al. Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Front Cell Neurosci. 2017;11:181 pubmed publisher
	Hegedüs L, Padányi R, Molnar J, Pászty K, Varga K, Kenessey I, et al. Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca2+ Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK. Front Oncol. 2017;7:95 pubmed publisher
	Knoflach D, Schicker K, GlÃ¶smann M, Koschak A. Gain-of-function nature of Cav1.4 L-type calcium channels alters firing properties of mouse retinal ganglion cells. Channels (Austin). 2015;9:298-306 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PMCA1 ATPase Polyclonal Antibody

Catalog # :

PA1-914

Quantity :

100 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Porcine, Rat

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:1,000

Species :

Human, Porcine, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/potassium pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.

Immunogen :

Synthetic peptide corresponding to the residues A(5) N N S V A Y S G V K N S I K E A N(22) of rat PMCA1 ATPase.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:1,000

Aliases :

2810442I22Rik; Atp2b1; ATPase plasma membrane Ca2+ transporting 1; ATPase, Ca++ transporting, plasma membrane 1; E130111D10Rik; plasma membrane Ca2+ pump (PMCA1b); plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium-transporting ATPase 1; PMCA1; Pmca1a; Pmca1b; Pmca1c; PMCA1kb

more info or order :

Invitrogen product webpage