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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Calsequestrin Polyclonal Antibody
catalog :
PA1-913
quantity :
100 uL
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, domestic sheep
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 50
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; fig s7b
Lewis H, Eminaga S, Gautel M, Avkiran M. Phosphorylation at Serines 157 and 161 Is Necessary for Preserving Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein Telethonin. Front Physiol. 2021;12:732020 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 3c
  • western blot; mouse; 1:1000; loading ...; fig s2f
Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  • western blot; human; 1:2500; loading ...; fig 1b
Amici D, Pinal Fernández I, Mázala D, Lloyd T, Corse A, Christopher Stine L, et al. Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun. 2017;5:24 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Gueffier M, Zintz J, Lambert K, Finan A, Aimond F, Chakouri N, et al. The TRPM4 channel is functionally important for the beneficial cardiac remodeling induced by endurance training. J Muscle Res Cell Motil. 2017;38:3-16 pubmed publisher
  • western blot; mouse; loading ...; fig 10
Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  • western blot; mouse; 1:1000; fig 5a
Huang M, Lee K, Kim K, Ahn M, Cho C, Kim D, et al. The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil. Exp Mol Med. 2016;48:e278 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Helms A, Alvarado F, Yob J, Tang V, Pagani F, Russell M, et al. Genotype-Dependent and -Independent Calcium Signaling Dysregulation in Human Hypertrophic Cardiomyopathy. Circulation. 2016;134:1738-1748 pubmed
  • western blot; mouse; 1:500; loading ...; fig 1b
Oláh T, Bodnár D, Tóth A, Vincze J, Fodor J, Reischl B, et al. Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol. 2016;594:7381-7398 pubmed publisher
  • western blot; human; fig 1
Wanichawan P, Hodne K, Hafver T, Lunde M, Martinsen M, Louch W, et al. Development of a high-affinity peptide that prevents phospholemman (PLM) inhibition of the sodium/calcium exchanger 1 (NCX1). Biochem J. 2016;473:2413-23 pubmed publisher
  • western blot; mouse; loading ...; fig 7a
Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach K, Grill A, et al. The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a. Cardiovasc Res. 2016;110:359-70 pubmed publisher
  • western blot; rat; fig 11
Hafver T, Hodne K, Wanichawan P, Aronsen J, Dalhus B, Lunde P, et al. Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman. J Biol Chem. 2016;291:4561-79 pubmed publisher
  • western blot; mouse; fig 3
Shimura D, Kusakari Y, Sasano T, Nakashima Y, Nakai G, Jiao Q, et al. Heterozygous deletion of sarcolipin maintains normal cardiac function. Am J Physiol Heart Circ Physiol. 2016;310:H92-103 pubmed publisher
Murzilli S, Serano M, Pietrangelo L, Protasi F, Paolini C. Structural Adaptation of the Excitation-Contraction Coupling Apparatus in Calsequestrin1-Null Mice during Postnatal Development. Biology (Basel). 2023;12: pubmed publisher
Cachorro E, G xfc nscht M, Schubert M, Sadek M, Siegert J, Dutt F, et al. CNP Promotes Antiarrhythmic Effects via Phosphodiesterase 2. Circ Res. 2023;132:400-414 pubmed publisher
Baraldo M, Zorzato S, Dondjang A, Geremia A, Nogara L, Dumitras A, et al. Inducible deletion of raptor and mTOR from adult skeletal muscle impairs muscle contractility and relaxation. J Physiol. 2022;600:5055-5075 pubmed publisher
Colombe A, Gerbaud P, Benitah J, Pidoux G. Housekeeping Proteins Exhibit a High Level of Expression Variability Within Control Group and Between Ischemic Human Heart Biopsies. J Am Heart Assoc. 2022;11:e026292 pubmed publisher
Bukowska A, Nikonova Y, Wolke C, Lendeckel U, Kocksk xe4 mper J, Goette A. Anti-inflammatory effects of endothelin receptor blockade in left atrial tissue of spontaneously hypertensive rats. Int J Cardiol Heart Vasc. 2022;42:101088 pubmed publisher
Balakrishnan R, Mareedu S, Babu G. Reducing sarcolipin expression improves muscle metabolism in mdx mice. Am J Physiol Cell Physiol. 2022;322:C260-C274 pubmed publisher
Butera G, Vecellio Reane D, Canato M, Pietrangelo L, Boncompagni S, Protasi F, et al. Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake. Cell Rep. 2021;35:109087 pubmed publisher
Parahuleva M, Kockskamper J, Heger J, Grimm W, Scherer A, Bühler S, et al. Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation in JDP2-Overexpressing Mice. Int J Mol Sci. 2020;21: pubmed publisher
Mareedu S, Pachon R, Thilagavathi J, Fefelova N, Balakrishnan R, Niranjan N, et al. Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice. Am J Physiol Heart Circ Physiol. 2021;320:H200-H210 pubmed publisher
Pluteanu F, Seidl M, Hamer S, Scholz B, Müller F. Inward Rectifier K+ Currents Contribute to the Proarrhythmic Electrical Phenotype of Atria Overexpressing Cyclic Adenosine Monophosphate Response Element Modulator Isoform CREM-IbΔC-X. J Am Heart Assoc. 2020;9:e016144 pubmed publisher
Kurekov xe1 S, Plaas M, Cagalinec M. Lack of functional wolframin causes drop in plasmalemmal sodium-calcium exchanger type 1 expression at early stage in rat model of Wolfram syndrome. Gen Physiol Biophys. 2020;39:499-503 pubmed publisher
Ambrogini P, Lattanzi D, Di Palma M, Ciacci C, Savelli D, Galati C, et al. Calsequestrin Deletion Facilitates Hippocampal Synaptic Plasticity and Spatial Learning in Post-Natal Development. Int J Mol Sci. 2020;21: pubmed publisher
Kumar M, Haghighi K, Kranias E, Sadayappan S. Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis. J Biol Chem. 2020;: pubmed publisher
Furlan S, Campione M, Murgia M, Mosole S, Argenton F, Volpe P, et al. Calsequestrins New Calcium Store Markers of Adult Zebrafish Cerebellum and Optic Tectum. Front Neuroanat. 2020;14:15 pubmed publisher
Liu T, Xiong F, Qi X, Xiao J, Villeneuve L, Abu Taha I, et al. Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts. JCI Insight. 2020;5: pubmed publisher
Van Opbergen C, Noorman M, Pfenniger A, Copier J, Vermij S, Li Z, et al. Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress. Int J Mol Sci. 2019;20: pubmed publisher
Pollak A, Liu C, Gudlur A, Mayfield J, Dalton N, Gu Y, et al. A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. elife. 2018;7: pubmed publisher
Molina C, Abu Taha I, Wang Q, Roselló Díez E, Kamler M, Nattel S, et al. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. 2018;9:1383 pubmed publisher
Makarewich C, Munir A, Schiattarella G, Bezprozvannaya S, Raguimova O, Cho E, et al. The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. elife. 2018;7: pubmed publisher
Jones J, Peana D, Veteto A, Lambert M, Nourian Z, Karasseva N, et al. TRPV4 increases cardiomyocyte calcium cycling and contractility yet contributes to damage in the aged heart following hypoosmotic stress. Cardiovasc Res. 2019;115:46-56 pubmed publisher
Tóth A, Schell R, Lévay M, Vettel C, Theis P, Haslinger C, et al. Inflammation leads through PGE/EP3 signaling to HDAC5/MEF2-dependent transcription in cardiac myocytes. EMBO Mol Med. 2018;10: pubmed publisher
Chakouri N, Reboul C, Boulghobra D, Kleindienst A, Nottin S, Gayrard S, et al. Stress-induced protein S-glutathionylation and phosphorylation crosstalk in cardiac sarcomeric proteins - Impact on heart function. Int J Cardiol. 2018;258:207-216 pubmed publisher
Wilder C, Pavlaki N, Dursun T, Gyimah P, Caldwell Dunn E, Ranieri A, et al. Facilitation of ischaemia-induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro. Br J Pharmacol. 2018;175:1669-1690 pubmed publisher
Flores D, Duong T, Brandenberger L, Mitra A, Shirali A, Johnson J, et al. Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell-type specific expression of Casq2 in the CPVT2 phenotype. Hum Mol Genet. 2018;27:1533-1544 pubmed publisher
Liu G, Zhu H, Cai W, Wang X, Jiang M, Essandoh K, et al. Regulation of BECN1-Mediated Autophagy by HSPB6: Insights from A Human HSPB6S10F Mutant. Autophagy. 2017;:1-56 pubmed publisher
Schobesberger S, Wright P, Tokar S, Bhargava A, Mansfield C, Glukhov A, et al. T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure. Cardiovasc Res. 2017;113:770-782 pubmed publisher
Goldenberg J, Wang X, Lewandowski E. Acyl CoA synthetase-1 links facilitated long chain fatty acid uptake to intracellular metabolic trafficking differently in hearts of male versus female mice. J Mol Cell Cardiol. 2016;94:1-9 pubmed publisher
Furlan S, Mosole S, Murgia M, Nagaraj N, Argenton F, Volpe P, et al. Calsequestrins in skeletal and cardiac muscle from adult Danio rerio. J Muscle Res Cell Motil. 2016;37:27-39 pubmed publisher
de Andrade P, Neff L, Strosova M, Arsenijevic D, Patthey Vuadens O, Scapozza L, et al. Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding. Front Physiol. 2015;6:254 pubmed publisher
Fantinato E, Milani L, Sironi G. Sox9 expression in canine epithelial skin tumors. Eur J Histochem. 2015;59:2514 pubmed publisher
Meschin P, Demion M, Cazorla O, Finan A, Thireau J, Richard S, et al. p11 modulates calcium handling through 5-HTâ‚„R pathway in rat ventricular cardiomyocytes. Cell Calcium. 2015;58:549-57 pubmed publisher
Ferretti R, Marques M, Khurana T, Santo Neto H. Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles. Physiol Rep. 2015;3: pubmed publisher
Rapti K, Stillitano F, Karakikes I, Nonnenmacher M, Weber T, Hulot J, et al. Effectiveness of gene delivery systems for pluripotent and differentiated cells. Mol Ther Methods Clin Dev. 2015;2:14067 pubmed publisher
Tóth A, Fodor J, Vincze J, Oláh T, Juhász T, Zákány R, et al. The Effect of SERCA1b Silencing on the Differentiation and Calcium Homeostasis of C2C12 Skeletal Muscle Cells. PLoS ONE. 2015;10:e0123583 pubmed publisher
Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, et al. Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation. FEBS Lett. 2015;589:1095-104 pubmed publisher
Lee C, Dagnino Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, et al. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skelet Muscle. 2015;5:4 pubmed publisher
Gehmlich K, Dodd M, Allwood J, Kelly M, Bellahcene M, Lad H, et al. Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy. Mol Biosyst. 2015;11:564-73 pubmed publisher
Carley A, Taglieri D, Bi J, Solaro R, Lewandowski E. Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I. Circ Heart Fail. 2015;8:119-27 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Calsequestrin Polyclonal Antibody
Catalog # :
PA1-913
Quantity :
100 uL
Price :
US 471.00
Clonality :
Polyclonal
Host :
Rabbit
Reactivity :
Canine, Human, Mouse, Ovine, Rat
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:500, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:10,000
Species :
Canine, Human, Mouse, Ovine, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium.
Immunogen :
Purified canine cardiac calsequestrin.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:100-1:500, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000-1:10,000
Aliases :
Aspartactin; calmitin; calmitine; calsequestrin; calsequestrin 1; calsequestrin 1 (fast-twitch, skeletal muscle); calsequestrin, skeletal muscle isoform; Calsequestrin-1; calsquestrin 1; CASQ; Casq1; CSQ; CSQ1; CSQ-1; Laminin-binding protein; PDIB1; sCSQ; skeletal muscle calsequestrin 1; VMCQA
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA