This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Syk Polyclonal Antibody
catalog :
PA1-9104
quantity :
100 ug
price :
US 464.00
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot
citations: 26
Reference
Morris J, Caragine C, Daniloski Z, Domingo J, Barry T, Lu L, et al. Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens. Science. 2023;380:eadh7699 pubmed publisher
Allen C, Croft D, Testard C, Brent L. Function of Trunk-Mediated "Greeting" Behaviours between Male African Elephants: Insights from Choice of Partners. Animals (Basel). 2021;11: pubmed publisher
Fisher A, Dodia C, Chatterjee S. A Peptide Inhibitor of Peroxiredoxin 6 Phospholipase A2 Activity Significantly Protects against Lung Injury in a Mouse Model of Ventilator Induced Lung Injury (VILI). Antioxidants (Basel). 2021;10: pubmed publisher
Haseeb A, Lefebvre V. The SOXE transcription factors-SOX8, SOX9 and SOX10-share a bi-partite transactivation mechanism. Nucleic Acids Res. 2019;47:6917-6931 pubmed publisher
Farrelly L, Thompson R, Zhao S, Lepack A, Lyu Y, Bhanu N, et al. Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019;567:535-539 pubmed publisher
Lu F, Portz B, Gilmour D. The C-Terminal Domain of RNA Polymerase II Is a Multivalent Targeting Sequence that Supports Drosophila Development with Only Consensus Heptads. Mol Cell. 2019;73:1232-1242.e4 pubmed publisher
Lu B, Klingbeil O, Tarumoto Y, Somerville T, Huang Y, Wei Y, et al. A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. Cancer Cell. 2018;34:970-981.e8 pubmed publisher
Nonomura K, Lukacs V, Sweet D, Goddard L, Kanie A, Whitwam T, et al. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation. Proc Natl Acad Sci U S A. 2018;115:12817-12822 pubmed publisher
Balashova N, Giannakakis A, Brown A, Koufos E, Benz R, Arakawa T, et al. Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli. Gene. 2018;672:106-114 pubmed publisher
Bhattacharjee S, Bose P, Patel K, Roy S, Gain C, Gowda H, et al. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Cell Death Dis. 2018;9:605 pubmed publisher
Stelekati E, Chen Z, Manne S, Kurachi M, Ali M, Lewy K, et al. Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155. Cell Rep. 2018;23:2142-2156 pubmed publisher
Guo L, Kim H, Wang H, Monaghan J, Freyermuth F, Sung J, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 2018;173:677-692.e20 pubmed publisher
Verma A, Lucas A, Verma S, Zhang Y, Josyula N, Khan A, et al. PheWAS and Beyond: The Landscape of Associations with Medical Diagnoses and Clinical Measures across 38,662 Individuals from Geisinger. Am J Hum Genet. 2018;102:592-608 pubmed publisher
Shinsky S, Christianson D. Polyamine Deacetylase Structure and Catalysis: Prokaryotic Acetylpolyamine Amidohydrolase and Eukaryotic HDAC10. Biochemistry. 2018;57:3105-3114 pubmed publisher
Xu H, Dahiya S, Wang L, Akimova T, Han R, Zhang T, et al. Utility of IL-2 Complexes in Promoting the Survival of Murine Orthotopic Forelimb Vascularized Composite Allografts. Transplantation. 2018;102:70-78 pubmed publisher
Xanthopoulos M, Walega R, Xiao R, Prasad D, Pipan M, Zemel B, et al. Caregiver-Reported Quality of Life in Youth with Down Syndrome. J Pediatr. 2017;189:98-104.e1 pubmed publisher
Wilmore J, Allman D. Here, There, and Anywhere? Arguments for and against the Physical Plasma Cell Survival Niche. J Immunol. 2017;199:839-845 pubmed publisher
Slone J, Pask G, Ferguson S, Millar J, Berger S, Reinberg D, et al. Functional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator. Proc Natl Acad Sci U S A. 2017;114:8586-8591 pubmed publisher
Gates S, Yokom A, Lin J, Jackrel M, Rizo A, Kendsersky N, et al. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 2017;357:273-279 pubmed publisher
Po P, Delaney E, Gamper H, Szantai Kis D, Speight L, Tu L, et al. Effect of Nascent Peptide Steric Bulk on Elongation Kinetics in the Ribosome Exit Tunnel. J Mol Biol. 2017;429:1873-1888 pubmed publisher
Hariri B, McMahon D, Chen B, Freund J, Mansfield C, Doghramji L, et al. Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem. 2017;292:8484-8497 pubmed publisher
Marouli E, Graff M, Medina Gomez C, Lo K, Wood A, Kjaer T, et al. Rare and low-frequency coding variants alter human adult height. Nature. 2017;542:186-190 pubmed publisher
Lazaridis I, Nadel D, Rollefson G, Merrett D, Rohland N, Mallick S, et al. Genomic insights into the origin of farming in the ancient Near East. Nature. 2016;536:419-24 pubmed
Marachelian A, Desai A, Balis F, Katzenstein H, Qayed M, Armstrong M, et al. Comparative pharmacokinetics, safety, and tolerability of two sources of ch14.18 in pediatric patients with high-risk neuroblastoma following myeloablative therapy. Cancer Chemother Pharmacol. 2016;77:405-12 pubmed publisher
Zhang H, Zhai Z, Zhou H, Li Y, Li X, Lin Y, et al. Puerarin Inhibits oxLDL-Induced Macrophage Activation and Foam Cell Formation in Human THP1 Macrophage. Biomed Res Int. 2015;2015:403616 pubmed publisher
Holmes M, Dale C, Zuccolo L, Silverwood R, Guo Y, Ye Z, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ. 2014;349:g4164 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Syk Polyclonal Antibody
Catalog # :
PA1-9104
Quantity :
100 ug
Price :
US 464.00
Clonality :
Polyclonal
Purity :
Ammonium sulfate precipitation
Host :
Goat
Reactivity :
Human
Applications :
Western Blot: 1-3 ug/mL
Species :
Human
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are viewed as potential druge targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer. Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
Immunogen :
Internal sequence corresponding to amino acids C-KYLQQNRHVKDKN (aa 458-471).
Format :
Liquid
Applications w/Dilutions :
Western Blot: 1-3 ug/mL
Aliases :
DKFZp313N1010; EC 2.7.10.2; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72Syk; p72-Syk; ptk72; SP1; spleen associated tyrosine kinase; spleen tyrosine kinase; SYK; syk signaling; Sykb; tyrosine-kinase syk; tyrosine-protein kinase SYK
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA