product summary
Loading...
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IP3 Receptor 1 Polyclonal Antibody
catalog :
PA1-901
quantity :
100 µL
price :
US 450.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; fig 5a
Dong J, Aulestia F, Assad Kahn S, Zeniou M, Dubois L, El Habr E, et al. Bisacodyl and its cytotoxic activity on human glioblastoma stem-like cells. Implication of inositol 1,4,5-triphosphate receptor dependent calcium signaling. Biochim Biophys Acta Mol Cell Res. 2017;1864:1018-1027 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 1b
Fouka P, Alexopoulos H, Chatzi I, Dedos S, Samiotaki M, Panayotou G, et al. Antibodies to inositol 1,4,5-triphosphate receptor 1 in patients with cerebellar disease. Neurol Neuroimmunol Neuroinflamm. 2017;4:e306 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 1
White J, Lin T, Brown A, Arancillo M, Lackey E, Stay T, et al. An optimized surgical approach for obtaining stable extracellular single-unit recordings from the cerebellum of head-fixed behaving mice. J Neurosci Methods. 2016;262:21-31 pubmed publisher
Coffin S, Durham M, Nitschke L, Xhako E, Brown A, Revelli J, et al. Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1. Neuron. 2023;111:481-492.e8 pubmed publisher
Liang J, Alevy J, Akhanov V, Seo R, Massey C, Jiang D, et al. Kctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects. Dis Model Mech. 2022;15: pubmed publisher
Botta S, Chemiakine A, Gennarino V. Dual antibody strategy for high-resolution imaging of murine Purkinje cells and their dendrites across multiple layers. STAR Protoc. 2022;3:101427 pubmed publisher
Hong T, Ham J, Song G, Lim W. Alpinumisoflavone Disrupts Endoplasmic Reticulum and Mitochondria Leading to Apoptosis in Human Ovarian Cancer. Pharmaceutics. 2022;14: pubmed publisher
Dulloo I, Atakpa Adaji P, Yeh Y, Levet C, Muliyil S, Lu F, et al. iRhom pseudoproteases regulate ER stress-induced cell death through IP3 receptors and BCL-2. Nat Commun. 2022;13:1257 pubmed publisher
Kwak Y, Shaw T, Downing S, Tewari A, Jin H, Li Y, et al. Chromatin architecture at susceptible gene loci in cerebellar Purkinje cells characterizes DNA damage-induced neurodegeneration. Sci Adv. 2021;7:eabg6363 pubmed publisher
Lim Y, Cho I, Rennke H, Cho G. β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep. 2021;11:21477 pubmed publisher
Kinoshita A, Ohyama K, Tanimura S, Matsuda K, Kishino T, Negishi Y, et al. Itpr1 regulates the formation of anterior eye segment tissues derived from neural crest cells. Development. 2021;148: pubmed publisher
Wang C, Dai X, Wu S, Xu W, Song P, Huang K. FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis. Nat Commun. 2021;12:2616 pubmed publisher
Bae H, Lee J, Song J, Song G, Lim W. Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer. J Cell Physiol. 2021;236:1025-1042 pubmed publisher
Bae H, Song G, Lim W. Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction. Pharmaceutics. 2020;12: pubmed publisher
Bae H, Lee J, Yang C, Song G, Lim W. Fucoidan Derived from Fucus vesiculosus Inhibits the Development of Human Ovarian Cancer via the Disturbance of Calcium Homeostasis, Endoplasmic Reticulum Stress, and Angiogenesis. Mar Drugs. 2020;18: pubmed publisher
Fink E, Moparthy S, Bagati A, Bianchi Smiraglia A, Lipchick B, Wolff D, et al. XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response. Cell Rep. 2018;25:212-223.e4 pubmed publisher
Ye X, Beckett T, Bagher P, Garland C, Dora K. VEGF-A inhibits agonist-mediated Ca2+ responses and activation of IKCa channels in mouse resistance artery endothelial cells. J Physiol. 2018;596:3553-3566 pubmed publisher
Garland C, Bagher P, Powell C, Ye X, Lemmey H, Borysova L, et al. Voltage-dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles. Sci Signal. 2017;10: pubmed publisher
Gennarino V, Singh R, White J, De Maio A, Han K, Kim J, et al. Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels. Cell. 2015;160:1087-98 pubmed publisher
Balghi H, Sebille S, Mondin L, Cantereau A, Constantin B, Raymond G, et al. Mini-dystrophin expression down-regulates IP3-mediated calcium release events in resting dystrophin-deficient muscle cells. J Gen Physiol. 2006;128:219-30 pubmed
Balghi H, Sebille S, Constantin B, Patri S, Thoreau V, Mondin L, et al. Mini-dystrophin expression down-regulates overactivation of G protein-mediated IP3 signaling pathway in dystrophin-deficient muscle cells. J Gen Physiol. 2006;127:171-82 pubmed
Clapp T, Stone L, Margolskee R, Kinnamon S. Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction. BMC Neurosci. 2001;2:6 pubmed
product information
Product Type :
Antibody
Product Name :
IP3 Receptor 1 Polyclonal Antibody
Catalog # :
PA1-901
Quantity :
100 µL
Price :
US 450.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Human, Mouse, Rat
Applications :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
Species :
Canine, Human, Mouse, Rat
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles
Description :
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Immunogen :
Synthetic Peptide: N(1829) K K K D D E V D R D A P S R K K A K E(1848)
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Frozen): 1:250, Immunoprecipitation: Assay-dependent, Western Blot: 1:1,000
Aliases :
ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; inositol 1,4,5-trisphosphate-binding protein P400; InsP>3<R type I; Insp3r; InsP3R type I; insP3R1; IP3 receptor; IP3 receptor isoform 1; Ip3r; IP-3-R; IP3R 1; IP3R1; Itpr1; Itpr-1; opisthotonus; opt; P400; Pcd6; Pcp1; Pcp-1; PPP1R94; protein PCD-6; protein phosphatase 1, regulatory subunit 94; Purkinje cell protein 1; SCA15; SCA16; SCA29; SI-SIII-SIIA; Type 1 inositol 1,4,5-trisphosphate receptor; type 1 InsP3 receptor
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA