MECP2 Polyclonal Antibody | Invitrogen PA1-887 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MECP2 Polyclonal Antibody

catalog :

PA1-887

quantity :

50 ug

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; fruit fly ; 1:5000; fig 2	Williams A, Mehler V, Mueller C, Vonhoff F, White R, Duch C. Apoptotic Activity of MeCP2 Is Enhanced by C-Terminal Truncating Mutations. PLoS ONE. 2016;11:e0159632 pubmed publisher
	Bueno C, Tabares Seisdedos R, Moraleda J, Martinez S. Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands. PLoS ONE. 2016;11:e0153262 pubmed publisher
	Williams A, White R, Siniard A, Corneveaux J, Huentelman M, Duch C. MECP2 impairs neuronal structure by regulating KIBRA. Neurobiol Dis. 2016;91:284-91 pubmed publisher

product information

Product Type :

Antibody

Product Name :

MECP2 Polyclonal Antibody

Catalog # :

PA1-887

Quantity :

50 ug

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Paraffin): 1:200-1:2,000, Immunoprecipitation: Assay-dependent, Western Blot: 1:1500

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3 and MBD4) that have a methyl-CpG binding domain. MECP2 is capable of binding specifically to methylated DNA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. MECP2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Immunogen :

Synthetic Peptide: M(1) V A G M L G L R E E K S E D(15) C

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:200, Immunohistochemistry (Paraffin): 1:200-1:2,000, Immunoprecipitation: Assay-dependent, Western Blot: 1:1500

Aliases :

1500041B07Rik; AUTSX3; D630021H01Rik; DKFZp686A24160; Mbd5; MECP2; MeCp-2 protein; methyl CpG binding protein 2; methyl-CpG binding protein 2; methyl-CpG-binding protein 2; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT; testis tissue sperm-binding protein Li 41a; WBP10

more info or order :

Invitrogen product webpage