Lactoferrin Polyclonal Antibody, HRP | Invitrogen PA1-86864 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Lactoferrin Polyclonal Antibody, HRP

catalog :

PA1-86864

quantity :

1 mL

price :

US 489

clonality :

polyclonal

host :

domestic sheep

conjugate :

HRP

reactivity :

human, dogs

application :

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Lactoferrin Polyclonal Antibody, HRP

Catalog # :

PA1-86864

Quantity :

1 mL

Price :

US 489

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Sheep

Reactivity :

Canine, Human

Applications :

ELISA: 1/50, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent

Species :

Canine, Human

Isotype :

IgG

Storage :

4°C or -20°C if preferred

Description :

Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.

Immunogen :

Lactoferrin purified from milk.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1/50, Immunohistochemistry (Frozen): Assay Dependent, Immunohistochemistry (Paraffin): Assay Dependent

Aliases :

GIG12, HLF2, LF