SLUG Polyclonal Antibody | Invitrogen PA1-86737 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SLUG Polyclonal Antibody

catalog :

PA1-86737

quantity :

100 ug

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 4

Reference
Wang Z, Shang J, Li Z, Li H, Zhang C, He K, et al. PIK3CA Is Regulated by CUX1, Promotes Cell Growth and Metastasis in Bladder Cancer via Activating Epithelial-Mesenchymal Transition. Front Oncol. 2020;10:536072 pubmed publisher
Li Y, Gong H, Feng L, Mao D, Xiao Y, Wang Y, et al. Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial-mesenchymal transition-related markers. FEBS Open Bio. 2021;11:423-434 pubmed publisher
Domenici G, Aurrekoetxea Rodríguez I, Simões B, Rábano M, Lee S, Millán J, et al. A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells. Oncogene. 2019;38:3151-3169 pubmed publisher
Karimzadeh F, Opas M. Calreticulin Is Required for TGF-Î²-Induced Epithelial-to-Mesenchymal Transition during Cardiogenesis in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017;8:1299-1311 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SLUG Polyclonal Antibody

Catalog # :

PA1-86737

Quantity :

100 ug

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry: Assay-dependent, Western Blot: 0.5-2 ug/mL

Species :

Human, Mouse

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.

Immunogen :

13 amino acid peptide sequence near the centre of human Slug

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry: Assay-dependent, Western Blot: 0.5-2 ug/mL

Aliases :

MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2