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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
HDAC1 Polyclonal Antibody
catalog :
PA1-860
quantity :
100 ug
price :
US 491.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
Chinese hamsters, human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 30
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; human; loading ...; fig 5
Schettino R, Verni M, Acin Albiac M, Vincentini O, Krona A, Knaapila A, et al. Bioprocessed Brewers' Spent Grain Improves Nutritional and Antioxidant Properties of Pasta. Antioxidants (Basel). 2021;10: pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 5
Ramaker R, Hardigan A, Gordon E, Wright C, Myers R, Cooper S. Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. BMC Cancer. 2021;21:632 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 5
Vitale F, Ortolan J, Volpe B, Marambaud P, Giliberto L, d Abramo C. Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models. Acta Neuropathol Commun. 2020;8:126 pubmed publisher
  • western blot; human; fig 2f
Li X, Eberhardt A, Hansen J, Bohmann D, Li H, Schor N. Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies. FASEB J. 2017;31:2327-2339 pubmed publisher
  • western blot; human; 1:1000; fig 6
E L, Swerdlow R. Lactate's effect on human neuroblastoma cell bioenergetic fluxes. Biochem Pharmacol. 2016;99:88-100 pubmed publisher
Bludau A, Neumann I, Menon R. HDAC1-mediated regulation of GABA signaling within the lateral septum facilitates long-lasting social fear extinction in male mice. Transl Psychiatry. 2023;13:10 pubmed publisher
Luo J, Li J, Li T, Zhang Z, Chen G, Li Q, et al. PIAS1 Alleviates Hepatic Ischemia-Reperfusion Injury in Mice through a Mechanism Involving NFATc1 SUMOylation. Dis Markers. 2022;2022:4988539 pubmed publisher
Paniagua I, Tayeh Z, Falcone M, Hern xe1 ndez P xe9 rez S, Cerutti A, Jacobs J. MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner. Nat Commun. 2022;13:5167 pubmed publisher
Xu x8bb8 x6f47 x4f9d X, He x4f55 x946b X, Zhang x5f20 x6cfd x5f66 Z, Chen x9648 x5f66 x4f0a Y, Li x9ece x4fca x5b87 J, Ma x9a6c x73ca x73ca S, et al. CREB inactivation by HDAC1/PP1γ contributes to dopaminergic neurodegeneration in Parkinson's disease. J Neurosci. 2022;42:4594-604 pubmed publisher
Litke C, Hagenston A, Kenkel A, Páldy E, Lu J, Kuner R, et al. Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice. Nat Commun. 2022;13:875 pubmed publisher
Sobczak M, Strachowska M, Gronkowska K, Karwaciak I, Pu x142 aski x, Robaszkiewicz A. LSD1 Facilitates Pro-Inflammatory Polarization of Macrophages by Repressing Catalase. Cells. 2021;10: pubmed publisher
Guo F, Zhang Y, Liu K, Huang X, Li R, Wang S, et al. Chronic Exposure to Alcohol Inhibits New Myelin Generation in Adult Mouse Brain. Front Cell Neurosci. 2021;15:732602 pubmed publisher
Lüdtke T, Wojahn I, Kleppa M, Schierstaedt J, Christoffels V, Künzler P, et al. Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung. Respir Res. 2021;22:85 pubmed publisher
Ohashi M, Hayes M, McChesney K, Johannsen E. Epstein-Barr virus nuclear antigen 3C (EBNA3C) interacts with the metabolism sensing C-terminal binding protein (CtBP) repressor to upregulate host genes. PLoS Pathog. 2021;17:e1009419 pubmed publisher
Wu C, Jin L, Wang I, Wei W, Ho P, Liu Y, et al. HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP-43 proteinopathies. EMBO Mol Med. 2020;12:e10622 pubmed publisher
Pao P, Patnaik D, Watson L, Gao F, Pan L, Wang J, et al. HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. Nat Commun. 2020;11:2484 pubmed publisher
Gilbert T, Zürcher N, Catanese M, Tseng C, Di Biase M, Lyall A, et al. Neuroepigenetic signatures of age and sex in the living human brain. Nat Commun. 2019;10:2945 pubmed publisher
Iershov A, Nemazanyy I, Alkhoury C, Girard M, Barth E, Cagnard N, et al. The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα. Nat Commun. 2019;10:1566 pubmed publisher
Patel N, Wang J, Shiozawa K, Jones K, Zhang Y, Prokop J, et al. HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression. iScience. 2019;13:43-54 pubmed publisher
Tempka D, Tokarz P, Chmielewska K, Kluska M, Pietrzak J, Rygielska Ż, et al. Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair. Redox Biol. 2018;15:316-326 pubmed publisher
Gao M, Chen T, Wu L, Zhao X, Mao H, Xing C. Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway. Mol Med Rep. 2017;16:6208-6213 pubmed publisher
Wiśnik E, Płoszaj T, Robaszkiewicz A. Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2-HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes. Sci Rep. 2017;7:9483 pubmed publisher
Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed publisher
Li J, He F, Zhang P, Chen S, Shi H, Sun Y, et al. Loss of Asxl2 leads to myeloid malignancies in mice. Nat Commun. 2017;8:15456 pubmed publisher
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
Dubey A, Copeland P. The Selenocysteine-Specific Elongation Factor Contains Unique Sequences That Are Required for Both Nuclear Export and Selenocysteine Incorporation. PLoS ONE. 2016;11:e0165642 pubmed publisher
Patrick N, Griggs C, Icenogle A, Gilpatrick M, Kadiyala V, Jaime Frias R, et al. Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1. J Steroid Biochem Mol Biol. 2017;167:1-13 pubmed publisher
Lebrun Julien F, Suter U. Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro. 2015;7: pubmed publisher
Zimberlin C, Lancini C, Sno R, Rosekrans S, McLean C, Vlaming H, et al. HDAC1 and HDAC2 collectively regulate intestinal stem cell homeostasis. FASEB J. 2015;29:2070-80 pubmed publisher
Levendusky M, Basle J, Chang S, Mandalaywala N, Voigt J, DEARBORN R. Expression and regulation of vitamin D3 upregulated protein 1 (VDUP1) is conserved in mammalian and insect brain. J Comp Neurol. 2009;517:581-600 pubmed publisher
product information
Product Type :
Antibody
Product Name :
HDAC1 Polyclonal Antibody
Catalog # :
PA1-860
Quantity :
100 ug
Price :
US 491.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Canine, Hamster, Human, Mouse, Rat
Applications :
ChIP Assay: 2.5 ug/10^6 cells, Immunocytochemistry: 2.0 ug/mL, Immunohistochemistry (Frozen): 0.2 ug/mL, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1 ug/mL
Species :
Canine, Hamster, Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.
Immunogen :
Synthetic peptide corresponding to residues C E(467) E K P E A K G V K E E V K L A(482) of human HDAC1.
Format :
Liquid
Applications w/Dilutions :
ChIP Assay: 2.5 ug/10^6 cells, Immunocytochemistry: 2.0 ug/mL, Immunohistochemistry (Frozen): 0.2 ug/mL, Immunohistochemistry (Paraffin): 1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1 ug/mL
Aliases :
DKFZp686H12203; GON-10; HD1; Hdac1; Hdac1-ps; Histone deacetylase 1; histone deacetylase 1-like protein; MommeD5; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; RPD3; RPD3L1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA