PPAR gamma-2 Polyclonal Antibody | Invitrogen PA1-824 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PPAR gamma-2 Polyclonal Antibody

catalog :

PA1-824

quantity :

100 uL

price :

US 500.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; 1:500; loading ...; fig 4c western blot; human; 1:500; loading ...; fig 4c	Qu B, Ma Y, Yan M, Gong K, Liang F, Deng S, et al. Sirtuin1 promotes osteogenic differentiation through downregulation of peroxisome proliferator-activated receptor ? in MC3T3-E1 cells. Biochem Biophys Res Commun. 2016;478:439-445 pubmed publisher
immunocytochemistry; human; fig 4	Bosetti M, Sabbatini M, Calarco A, Borrone A, Peluso G, Cannas M. Effect of retinoic acid and vitamin D3 on osteoblast differentiation and activity in aging. J Bone Miner Metab. 2016;34:65-78 pubmed publisher
	Zonderland J, Moldero I, Anand S, Mota C, Moroni L. Dimensionality changes actin network through lamin A/C and zyxin. Biomaterials. 2020;240:119854 pubmed publisher
	Li D, Ikaga R, Yamazaki T. Soya protein β-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ. Br J Nutr. 2018;119:1220-1232 pubmed publisher
	Chang J, Ha K. A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes. PLoS ONE. 2018;13:e0195007 pubmed publisher
	Gong K, Qu B, Wang C, Zhou J, Liao D, Zheng W, et al. Peroxisome Proliferator-Activated Receptor Î± Facilitates Osteogenic Differentiation in MC3T3-E1 Cells via the Sirtuin 1-Dependent Signaling Pathway. Mol Cells. 2017;40:393-400 pubmed publisher
	Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
	Langhi L, Andrade L, Shimabukuro M, van Ewijk W, Taub D, Borojevic R, et al. Lipid-Laden Multilocular Cells in the Aging Thymus Are Phenotypically Heterogeneous. PLoS ONE. 2015;10:e0141516 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PPAR gamma-2 Polyclonal Antibody

Catalog # :

PA1-824

Quantity :

100 uL

Price :

US 500.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:500, Western Blot: 1:500

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed peroxisome proliferator activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR gamma 2, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex.

Immunogen :

Synthetic peptide corresponding to residues M(1) G E T L G D S P I D P E S D S(16) C of human PPAR gamma-2.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:500, Western Blot: 1:500

Aliases :

CIMT1; GLM1; Nr1c3; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; PPARG; PPARG1; PPARG2; PPARgamma; PPAR-gamma; PPARgamma2; PPAR-gamma2

more info or order :

Invitrogen product webpage