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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PPAR delta Polyclonal Antibody
catalog :
PA1-823A
quantity :
100 uL
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 19
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 4a
Zhu K, Tang Y, Xu X, Dang H, Tang L, Wang X, et al. Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis. PLoS Biol. 2018;16:e3000091 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4b
Gong K, Qu B, Liao D, Liu D, Wang C, Zhou J, et al. MiR-132 regulates osteogenic differentiation via downregulating Sirtuin1 in a peroxisome proliferator-activated receptor ?/?-dependent manner. Biochem Biophys Res Commun. 2016;478:260-267 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200; fig 1
Chang G, Karatayev O, Lukatskaya O, Leibowitz S. Prenatal fat exposure and hypothalamic PPAR ?/?: Possible relationship to increased neurogenesis of orexigenic peptide neurons. Peptides. 2016;79:16-26 pubmed publisher
  • western blot; mouse; 1:100; fig s7
Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53-8 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 2
  • western blot; human; 1:1000; fig 1
Dickey A, Pineda V, Tsunemi T, Liu P, Miranda H, Gilmore Hall S, et al. PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016;22:37-45 pubmed publisher
Covatti C, Mizobuti D, Rocha G, da Silva H, de Louren xe7 o C, Pertille A, et al. Low-Level Photobiomodulation Therapy Modulates H2O2 Production, TRPC-6, and PGC-1α Levels in the Dystrophic Muscle. Photobiomodul Photomed Laser Surg. 2023;41:389-401 pubmed publisher
He H, Zhong Y, Wang H, Tang P, Xue V, Chen X, et al. Smad3 Mediates Diabetic Dyslipidemia and Fatty Liver in db/db Mice by Targeting PPARδ. Int J Mol Sci. 2023;24: pubmed publisher
Oliveira A, Oliveira L, Cruz M, Guimar xe3 es D, Lima T, Santos F xe1 vero B, et al. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. J Biol Chem. 2023;299:104702 pubmed publisher
Larson Casey J, Liu S, Pyles J, Lapi S, Saleem K, Antony V, et al. Impaired PPARγ activation by cadmium exacerbates infection-induced lung injury. JCI Insight. 2023;8: pubmed publisher
Mizobuti D, da Rocha G, da Silva H, Covatti C, de Louren xe7 o C, Pereira E, et al. Antioxidant effects of bis-indole alkaloid indigo and related signaling pathways in the experimental model of Duchenne muscular dystrophy. Cell Stress Chaperones. 2022;27:417-429 pubmed publisher
Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, et al. N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021;12:6314 pubmed publisher
Hidalgo Guti xe9 rrez A, Barriocanal Casado E, D xed az Casado M, Gonz xe1 lez Garc xed a P, Zenezini Chiozzi R, Acu xf1 a Castroviejo D, et al. β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight. Biomedicines. 2021;9: pubmed publisher
da Silva H, Covatti C, da Rocha G, Mizobuti D, Mancio R, Hermes T, et al. Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained-mdx Mice. Front Physiol. 2021;12:649793 pubmed publisher
Zhang Q, Zhang Y, Sun S, Wang K, Qian J, Cui Z, et al. ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. Cell Death Dis. 2021;12:15 pubmed publisher
Kotula Balak M, Gorowska Wojtowicz E, Milon A, Pawlicki P, Tworzydlo W, Płachno B, et al. Towards understanding leydigioma: do G protein-coupled estrogen receptor and peroxisome proliferator-activated receptor regulate lipid metabolism and steroidogenesis in Leydig cell tumors?. Protoplasma. 2020;257:1149-1163 pubmed publisher
Hao Y, Lafita Navarro M, Zacharias L, Borenstein Auerbach N, Kim M, Barnes S, et al. Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation. Cell Commun Signal. 2019;17:129 pubmed publisher
Mikalayeva V, Ceslevičienė I, Sarapinienė I, Žvikas V, Skeberdis V, Jakstas V, et al. Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Kinouchi K, Magnan C, Ceglia N, Liu Y, Cervantes M, Pastore N, et al. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep. 2018;25:3299-3314.e6 pubmed publisher
Haffar T, Bérubé Simard F, Bousette N. Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs. Biochem Biophys Res Commun. 2015;459:54-9 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PPAR delta Polyclonal Antibody
Catalog # :
PA1-823A
Quantity :
100 uL
Price :
US 471.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry (Frozen): 1:200, Western Blot: 1:250-1:1,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Immunogen :
Synthetic peptide corresponding to residues M(1) E Q P Q E E T P E A R E E(14) C of mouse PPAR delta.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1-2 ug/mL, Immunohistochemistry (Frozen): 1:200, Western Blot: 1:250-1:1,000
Aliases :
FAAR; MGC3931; Nr1c2; NUC1; NUC-1; NUCI; NUCII; nuclear hormone receptor; nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferative activated receptor delta; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor beta; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor delta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR[b]; PPARB; Pparb/d; PPARbeta; PPAR-beta; Ppard; PPARdelta; PPAR-delta; PPARdelta/beta
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA