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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
PPAR alpha Polyclonal Antibody
catalog :
PA1-822A
quantity :
100 uL
price :
US 471.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3s3b
Contat C, Ancey P, Zangger N, Sabatino S, Pascual J, Escrig S, et al. Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 6i
Milligan S, Martin G, Landrock D, McIntosh A, Mackie J, Schroeder F, et al. Impact of dietary phytol on lipid metabolism in SCP2/SCPX/L-FABP null mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:291-304 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; fig 1
  • western blot; human; 1:400; fig 4
Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
  • western blot; human; 1:1000; fig 1
  • immunohistochemistry; mouse; 1:200; fig 2
Dickey A, Pineda V, Tsunemi T, Liu P, Miranda H, Gilmore Hall S, et al. PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016;22:37-45 pubmed publisher
Xiang G, Liu X, Wang J, Lu S, Yu M, Zhang Y, et al. Peroxisome proliferator-activated receptor-α activation facilitates contextual fear extinction and modulates intrinsic excitability of dentate gyrus neurons. Transl Psychiatry. 2023;13:206 pubmed publisher
Liu Y, Duan Y, Zhao N, Zhu X, Yu X, Jiao S, et al. Peroxisome Proliferator-Activated Receptor α Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Angiotensin II-Induced ROS Production. Antioxidants (Basel). 2022;11: pubmed publisher
Liebmann M, Grupe K, Asuaje Pfeifer M, Rustenbeck I, Scherneck S. Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate. Lipids Health Dis. 2022;21:99 pubmed publisher
Guo X, Dang W, Li N, Wang Y, Sun D, Nian H, et al. PPAR-α Agonist Fenofibrate Ameliorates Sjögren Syndrome-Like Dacryoadenitis by Modulating Th1/Th17 and Treg Cell Responses in NOD Mice. Invest Ophthalmol Vis Sci. 2022;63:12 pubmed publisher
Lickwar C, Davison J, Kelly C, Mercado G, Wen J, Davis B, et al. Transcriptional Integration of Distinct Microbial and Nutritional Signals by the Small Intestinal Epithelium. Cell Mol Gastroenterol Hepatol. 2022;14:465-493 pubmed publisher
Dhanyalayam D, Thangavel H, Lizardo K, Oswal N, Dolgov E, Perlin D, et al. Sex Differences in Cardiac Pathology of SARS-CoV2 Infected and Trypanosoma cruzi Co-infected Mice. Front Cardiovasc Med. 2022;9:783974 pubmed publisher
Men H, Young J, Zhou W, Zhang H, Wang X, Xu J, et al. Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer. Oxid Med Cell Longev. 2021;2021:1427787 pubmed publisher
Börsch A, Ham D, Mittal N, Tintignac L, Migliavacca E, Feige J, et al. Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia. Commun Biol. 2021;4:194 pubmed publisher
Zhang Q, Zhang Y, Sun S, Wang K, Qian J, Cui Z, et al. ACOX2 is a prognostic marker and impedes the progression of hepatocellular carcinoma via PPARα pathway. Cell Death Dis. 2021;12:15 pubmed publisher
Avraham O, Deng P, Jones S, Kuruvilla R, Semenkovich C, Klyachko V, et al. Satellite glial cells promote regenerative growth in sensory neurons. Nat Commun. 2020;11:4891 pubmed publisher
Lin X, Shao T, Huang L, Wen X, Wang M, Wen C, et al. Simiao Decoction Alleviates Gouty Arthritis by Modulating Proinflammatory Cytokines and the Gut Ecosystem. Front Pharmacol. 2020;11:955 pubmed publisher
Lizardo K, Ayyappan J, Ganapathi U, Dutra W, Qiu Y, Weiss L, et al. Diet Alters Serum Metabolomic Profiling in the Mouse Model of Chronic Chagas Cardiomyopathy. Dis Markers. 2019;2019:4956016 pubmed publisher
Lim S, Park J, Um J. Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor-Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice. Front Pharmacol. 2019;10:1154 pubmed publisher
Nogueira Recalde U, Lorenzo Gómez I, Blanco F, Loza M, Grassi D, Shirinsky V, et al. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy. EBioMedicine. 2019;45:588-605 pubmed publisher
Siong Tan H, Anjum B, Shen H, Ghosh S, Yen P, Sinha R. Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels. Autophagy. 2019;15:1455-1459 pubmed publisher
McIntosh A, Atshaves B, Martin G, Landrock D, Milligan S, Landrock K, et al. Effect of liver fatty acid binding protein (L-FABP) gene ablation on lipid metabolism in high glucose diet (HGD) pair-fed mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:985-1004 pubmed publisher
Martin G, Landrock D, Dangott L, McIntosh A, Kier A, Schroeder F. Human Liver Fatty Acid Binding Protein-1 T94A Variant, Nonalcohol Fatty Liver Disease, and Hepatic Endocannabinoid System. Lipids. 2018;53:27-40 pubmed publisher
Goncalves M, Hwang S, Pauli C, Murphy C, Cheng Z, Hopkins B, et al. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proc Natl Acad Sci U S A. 2018;115:E743-E752 pubmed publisher
Milligan S, Martin G, Landrock D, McIntosh A, Mackie J, Schroeder F, et al. Ablating both Fabp1 and Scp2/Scpx (TKO) induces hepatic phospholipid and cholesterol accumulation in high fat-fed mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:323-338 pubmed publisher
Gong K, Qu B, Wang C, Zhou J, Liao D, Zheng W, et al. Peroxisome Proliferator-Activated Receptor α Facilitates Osteogenic Differentiation in MC3T3-E1 Cells via the Sirtuin 1-Dependent Signaling Pathway. Mol Cells. 2017;40:393-400 pubmed publisher
Landrock D, Milligan S, Martin G, McIntosh A, Landrock K, Schroeder F, et al. Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice. Lipids. 2017;52:385-397 pubmed publisher
Chang G, Karatayev O, Lukatskaya O, Leibowitz S. Prenatal fat exposure and hypothalamic PPAR ?/?: Possible relationship to increased neurogenesis of orexigenic peptide neurons. Peptides. 2016;79:16-26 pubmed publisher
Martin G, Landrock D, Landrock K, Howles P, Atshaves B, Kier A, et al. Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice. Arch Biochem Biophys. 2015;588:25-32 pubmed publisher
Martin G, Atshaves B, Landrock K, Landrock D, Schroeder F, Kier A. Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice. Arch Biochem Biophys. 2015;580:41-9 pubmed publisher
Klipsic D, Landrock D, Martin G, McIntosh A, Landrock K, Mackie J, et al. Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation. Am J Physiol Gastrointest Liver Physiol. 2015;309:G387-99 pubmed publisher
product information
Product Type :
Antibody
Product Name :
PPAR alpha Polyclonal Antibody
Catalog # :
PA1-822A
Quantity :
100 uL
Price :
US 471.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1.0 ug/mL
Species :
Human, Mouse
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferator activated receptors (PPAR's). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPAR's are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPAR's can induce transcription of acyl coenzyme A oxidase & cytochrome P450 (CYP450) A6 through interaction with specific response elements. PPAR, like several other nuclear hormone receptors, heterodimerizes with retinoid X receptor (RXR) alpha.
Immunogen :
Synthetic peptide corresponding to residues M(1) V D T E S P I C P L S P L E A D D(18) C of mouse PPAR alpha.
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100, Immunoprecipitation: Assay-dependent, Western Blot: 1.0 ug/mL
Aliases :
4933429D07Rik; AW742785; hPPAR; I79_022392; MGC2237; MGC2452; Nr1c1; nuclear hormone receptor; nuclear receptor; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor alpha; peroxisome proliferative activated receptor, alpha; peroxisome proliferative activated receptor, alpha isoform 1; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; PPAR; PPAR ALPHA; Ppara; PPARALPHA; PPAR-alpha; proliferator-activated receptor alpha; transcription factor belonging to the nuclear receptor superfamily
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA