TPH2 Polyclonal Antibody | Invitrogen PA1-778 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TPH2 Polyclonal Antibody

catalog :

PA1-778

quantity :

100 uL

price :

US 471.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; loading ...; fig 1b	Sahu M, Pazos Boubeta Y, Steinzeig A, Kaurinkoski K, Palmisano M, Borowecki O, et al. Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory. Front Mol Neurosci. 2021;14:616178 pubmed publisher
western blot; rat; 1:500; loading ...	Holschbach M, Lonstein J. Motherhood and infant contact regulate neuroplasticity in the serotonergic midbrain dorsal raphe. Psychoneuroendocrinology. 2017;76:97-106 pubmed publisher
western blot; rat; 1:1000; fig 7.8	Ragan C, Harding K, Lonstein J. Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats. Horm Behav. 2016;77:62-71 pubmed publisher
	Collins S, Stinson H, Himes A, Nestor Kalinoski A, Ninan I. Sex-specific modulation of the medial prefrontal cortex by glutamatergic median raphe neurons. Sci Adv. 2023;9:eadg4800 pubmed publisher
	Zhao P, Wang H, Li A, Sun Q, Jiang T, Li X, et al. The Mesoscopic Connectome of the Cholinergic Pontomesencephalic Tegmentum. Front Neuroanat. 2022;16:843303 pubmed publisher
	Haase J, Jones A, Mc Veigh C, Brown E, Clarke G, Ahnert Hilger G. Sex and brain region-specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice. J Neurochem. 2021;159:156-171 pubmed publisher
	Horii K, Ehara Y, Shiina T, Naitou K, Nakamori H, Horii Y, et al. Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats. J Physiol. 2021;599:1421-1437 pubmed publisher
	Takada T, Yoneda N, Hirano T, Onaru K, Mantani Y, Yokoyama T, et al. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. J Vet Med Sci. 2020;82:350-359 pubmed publisher
	Prakash N, Stark C, Keisler M, Luo L, Der Avakian A, Dulcis D. Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia. J Neurosci. 2020;40:569-584 pubmed publisher
	Shokry I, Shields C, Callanan J, Ma Z, Tao R. Differential role of dose and environment in initiating and intensifying neurotoxicity caused by MDMA in rats. BMC Pharmacol Toxicol. 2019;20:47 pubmed publisher
	Park Y, Sohn C, Chen R, McCue M, Yun D, Drummond G, et al. Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nat Biotechnol. 2018;: pubmed publisher
	Yokoyama T, Nakamuta N, Kusakabe T, Yamamoto Y. Sympathetic regulation of vascular tone via noradrenaline and serotonin in the rat carotid body as revealed by intracellular calcium imaging. Brain Res. 2015;1596:126-35 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TPH2 Polyclonal Antibody

Catalog # :

PA1-778

Quantity :

100 uL

Price :

US 471.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate, Rabbit, Rat

Applications :

Immunocytochemistry: 1:500, Immunoprecipitation: 1:1,000, Western Blot: 1:1,000

Species :

Human, Mouse, Non-human primate, Rabbit, Rat

Isotype :

IgG

Storage :

4 C

Description :

Tryptophan hydroxylase (TPH) is a member of the pterin-dependent aromatic acid hydroxylase family. It catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. TPH is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Immunogen :

Synthetic peptide corresponding to the N-terminal region of TPH2: R(15) R G L S L D S A V P E D H Q L (30)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:500, Immunoprecipitation: 1:1,000, Western Blot: 1:1,000

Aliases :

ADHD7; AU043594; MGC119994; Neuronal tryptophan hydroxylase; NTPH; Tph2; TPRH; TRPH; Tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2; tryptophan hydroxylase 2

more info or order :

Invitrogen product webpage