BACE1 Polyclonal Antibody | Invitrogen PA1-757 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BACE1 Polyclonal Antibody

catalog :

PA1-757

quantity :

100 ug

price :

US 451.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 7a	Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
immunocytochemistry; mouse; 1:850; loading ...; fig 4e	Ubelmann F, Burrinha T, Salavessa L, Gomes R, Ferreira C, Moreno N, et al. Bin1 and CD2AP polarise the endocytic generation of beta-amyloid. EMBO Rep. 2017;18:102-122 pubmed publisher
western blot; human; 1:1000; fig 1	Natunen T, Takalo M, Kemppainen S, LeskelÃ¤ S, Marttinen M, Kurkinen K, et al. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. Neurobiol Dis. 2016;85:187-205 pubmed publisher
	Jin J, Xu Z, Zhang L, Zhang C, Zhao X, Mao Y, et al. Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis. Gut Microbes. 2023;15:2167172 pubmed publisher
	Nasser S, Abdallah D, Ahmed K, Abdel Mottaleb Y, El Abhar H. The novel anti-colitic effect of β-adrenergic receptors via modulation of PS1/BACE-1/Aβ axis and NOTCH signaling in an ulcerative colitis model. Front Pharmacol. 2022;13:1008085 pubmed publisher
	Ollonen T, Kurkela M, Laitakari A, Sakko S, Koivisto H, Myllyharju J, et al. Activation of the hypoxia response protects mice from amyloid-β accumulation. Cell Mol Life Sci. 2022;79:432 pubmed publisher
	Lee J, Ostalecki C, Oberstein T, Schierer S, Zinser E, Eberhardt M, et al. Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus. EBioMedicine. 2022;77:103903 pubmed publisher
	Chaves R, Tran M, Holder A, Balcer A, Dickey A, Roberts E, et al. Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons. J Neurosci. 2021;41:10034-10053 pubmed publisher
	Burrinha T, Martinsson I, Gomes R, Terrasso A, Gouras G, Almeida C. Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss. J Cell Sci. 2021;134: pubmed publisher
	Chaudhari K, Wang L, Kruse J, Winters A, Sumien N, Shetty R, et al. Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease. Neurol Res. 2021;43:570-581 pubmed publisher
	Liu L, Ding L, Rovere M, Wolfe M, Selkoe D. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. J Cell Biol. 2019;218:644-663 pubmed publisher
	Wang H, Sang N, Zhang C, Raghupathi R, Tanzi R, SAUNDERS A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 2015;54:2806-16 pubmed publisher

product information

Product Type :

Antibody

Product Name :

BACE1 Polyclonal Antibody

Catalog # :

PA1-757

Quantity :

100 ug

Price :

US 451.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:2,000

Species :

Human, Mouse

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

BACE1 (beta-secretase) is a key enzyme involved in the production of amyloid beta-peptides (Abeta) found in extracellular amyloid plaques of Alzheimer's disease (AD). In some cases early onset familial AD can be attributed to a Swedish mutation in the amyloid precursor protein (APP), which dramatically enhances the cleavage of this protein by BACE1. This and other genetic and pathological evidence has led to therapeutic approaches that have focused on the inhibition of BACE1 and other APP-cleaving enzymes, such as gamma-secretase stuff. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4 kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Immunogen :

Synthetic peptide corresponding to residues C(485) L R Q Q H D D F A D D I S L L K(501) of human beta-secretase.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:20-1:200, Immunoprecipitation: Assay-dependent, Western Blot: 1:200-1:2,000

Aliases :

APP beta-secretase; asp 2; ASP2; Aspartyl protease 2; BACE; BACE 1; BACE1; BACE-1D; BACE-I-432; Beta secretase; Beta-secretase 1; beta-secretase 1 precursor variant 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; C76936; HSPC104; hypothetical protein LOC403005; KIAA1149; Memapsin; Memapsin2; Memapsin-2; membrane-associated aspartic protease 2; protease; transmembrane aspartic proteinase Asp2; zgc:77409

more info or order :

Invitrogen product webpage