Ataxin 7 Polyclonal Antibody | Invitrogen PA1-749 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Ataxin 7 Polyclonal Antibody

catalog :

PA1-749

quantity :

100 ug

price :

US 490.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, fruit fly

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100; loading ...; fig 1c	Fiszer A, Wroblewska J, Nowak B, Krzyzosiak W. Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells. Genes (Basel). 2016;7: pubmed publisher
immunohistochemistry - frozen section; human; 1:2000; fig 1 western blot; human; 1:2000; fig 1	Alves S, Marais T, Biferi M, Furling D, Marinello M, El Hachimi K, et al. Lentiviral vector-mediated overexpression of mutant ataxin-7 recapitulates SCA7 pathology and promotes accumulation of the FUS/TLS and MBNL1 RNA-binding proteins. Mol Neurodegener. 2016;11:58 pubmed publisher
	Zhang N, Bewick B, Schultz J, Tiwari A, Krencik R, Zhang A, et al. DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases. Neurotherapeutics. 2021;: pubmed publisher
	Fusco A, Pucci L, Switonski P, Biswas D, McCall A, Kahn A, et al. Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7. Dis Model Mech. 2021;14: pubmed publisher
	Niewiadomska Cimicka A, Doussau F, Perot J, Roux M, Keime C, Hache A, et al. SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2. J Neurosci. 2021;41:4910-4936 pubmed publisher
	Ward J, Stoyas C, Switonski P, Ichou F, Fan W, Collins B, et al. Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease. Cell Rep. 2019;26:1189-1202.e6 pubmed publisher
	Guyenet S, Mookerjee S, Lin A, Custer S, Chen S, Sopher B, et al. Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction. Hum Mol Genet. 2015;24:3908-17 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Ataxin 7 Polyclonal Antibody

Catalog # :

PA1-749

Quantity :

100 ug

Price :

US 490.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Drosophila, Human

Applications :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1 ug/mL

Species :

Drosophila, Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Spinocerebellar ataxia type 7 (SCA7) belongs to a class of hereditary neurodegenrative diseases characterized by abnormally expanded polyglutamine (CAG) repeats at the N-terminus. This autosomal dominant cerebellar ataxia primarily affects the cerebellum, retina, and brain stem and causes dementia, macular degeneration and other neurodegenerative characteristics. SCA7 gene encodes the ubiquitous 892 residue protein ataxin-7. This protein is typically located in the cytoplasm and on the nuclear membrane of normal brain neurons. In cells where there is a mutation of the SCA7 gene, ataxin 7 accumulates in intranuclear inclusions and can result in cell death.

Immunogen :

Synthetic Peptide: M(1) S E R A A D D V R G E P R R A A(17) C

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: 1 ug/mL

Aliases :

A430107N12Rik; ADCAII; AI627028; Ataxin 7; Ataxin7; Ataxin-7; ATXN7; Atxn7-PA; Atxn7-PB; Atxn7-PC; Atxn7-PD; CG9866; CG9866-PA; CG9866-PB; CG9866-PC; CG9866-PD; Dmel CG9866; Dmel_CG9866; LD40170p; OPCA3; RGD1562692; SCA7; spinocerebellar ataxia 7 homolog; spinocerebellar ataxia type 7 protein; Spinocerebellar ataxia type 7 protein homolog

more info or order :

Invitrogen product webpage