TRPV1 Polyclonal Antibody | Invitrogen PA1-748 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRPV1 Polyclonal Antibody

catalog :

PA1-748

quantity :

100 ug

price :

US 465.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:200; fig 1	Pecze L, Jósvay K, Blum W, Petrovics G, Vizler C, Olah Z, et al. Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons. Biochim Biophys Acta. 2016;1863:2054-64 pubmed publisher
	Nimbalkar S, Guo X, Col xf3 n A, Jackson M, Akanda N, Patel A, et al. Development of a functional human induced pluripotent stem cell-derived nociceptor MEA system as a pain model for analgesic drug testing. Front Cell Dev Biol. 2023;11:1011145 pubmed publisher
	Shiers S, Sankaranarayanan I, Jeevakumar V, Cervantes A, Reese J, Price T. Convergence of peptidergic and non-peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn. J Comp Neurol. 2021;529:2771-2788 pubmed publisher
	Lv G, Zhu G, Xu M, Gao X, Xiao Q. Inhibition of carrageenan-induced dental inflammatory responses owing to decreased TRPV1 activity by Dexmedetomidine. J Inflamm (Lond). 2020;17:18 pubmed publisher
	Han G, Chay D, Nam S, Cho H, Chung J, Kim J. Prognostic Significance of Transient Receptor Potential Vanilloid Type 1 (TRPV1) and Phosphatase and Tension Homolog (PTEN) in Epithelial Ovarian Cancer. Cancer Genomics Proteomics. 2020;17:309-319 pubmed publisher
	Xiao F, Zhou Y, Liu Y, Xie M, Guo G. Inhibitory Effect of Sirtuin6 (SIRT6) on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells. Med Sci Monit. 2019;25:8412-8421 pubmed publisher
	Roet M, Jansen A, Hoogland G, Temel Y, Jahanshahi A. Endogenous TRPV1 expression in the human cingulate- and medial frontal gyrus. Brain Res Bull. 2019;152:184-190 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TRPV1 Polyclonal Antibody

Catalog # :

PA1-748

Quantity :

100 ug

Price :

US 465.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Frozen): 1 ug/mL

Species :

Human

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

Immunogen :

Synthetic peptide corresponding to residues T(7) D L G A A A D P L Q K D T C(21) of human VR1.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1 ug/mL

Aliases :

Capsaicin receptor; cation channel; DKFZp434K0220; non-selective cation channel; osm-9-like TRP channel 1; OTRPC1; si:dkey-9e15.2; transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential V1; transient receptor potential V1 channel; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TRPV1; TRPV1/2; TRPV1_SON; TRPV1alpha; TRPV1beta; Vanilloid receptor; vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor; VR.5'sv; Vr1; VR-1; Vr1l; Vr1l1

more info or order :

Invitrogen product webpage