Factor V Polyclonal Antibody | Invitrogen PA1-74106 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

Factor V Polyclonal Antibody

catalog :

PA1-74106

quantity :

10 mg

price :

US 299

clonality :

polyclonal

host :

sheep

reactivity :

human, dog, pig

product information

Product Type :

PA1-74106

Product Name :

Factor V Polyclonal Antibody

Catalog # :

PA1-74106

Quantity :

10 mg

Price :

US 299

Clonality :

Polyclonal

Purity :

purified

Host :

Sheep

Reactivity :

Canine, Human, Porcine, Rabbit

Applications :

ELISA, Immunoelectrophoresis and Inhibition Assays

Species :

Ca, Hu, Po, Rb

Gene Identification :

Entrez: 100685858, 2153, 397217; Uniprot: P12259, Q9GLP1

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Factor V (formerly referred to as accelerator globulin and labile factor) is a large glycoprotein (320kDa) that is produced in the liver. The gene that encodes factor V (F.V) is located on the chromosome 1. A congenital deficiency of F.V is a hemorrhagic disorder inherited as an autosomal recessive disease. The concentration of F.V in plasma is typically 10µg/ml. F.V is a pro-cofactor that is activated through limited proteolysis by thrombin, or by activated factor X in the proscence of phospholipid surface. Other physiologic activators of F.V include plasmin, neutrophil elastase and platelet calpain. The activated cofactor (F.Va) is an essential component of the prothrombin activator complex, which consists of F.Va, activated factor X, calcium and anionic phospholipid surface. The intact prothrombinase complex activates prothrombin to thrombin at a rate 300,000-fold greater than activated factor X alone. In a positive feedback loop, the thrombin generated accelerates its own generation by activating more F.V to F.Va. Thrombin also acts to down regulate F.Va indirectly by activating protein C, which inactivates F.Va cofactor activity^1-3.

Immunogen :

Factor V from human plasma.

Format :

Liquid; 0.01 M HEPES, 50 % glycerol, 0.15 M NaCl, no preservative

Applications w/Dilutions :

ELISA Assay Dependent, IA Assay Dependent, IE Assay Dependent

Aliases :

FVL, PCCF