PDE6 gamma Polyclonal Antibody | Invitrogen PA1-723 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PDE6 gamma Polyclonal Antibody

catalog :

PA1-723

quantity :

100 µL

price :

US 428

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

bovine, domestic sheep

application :

western blot

citations: 1

Reference
Kang D, Sp N, Jo E, Lee J, Jang K. New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes. Cells. 2021;10: pubmed publisher

product information

Product Type :

Antibody

Product Name :

PDE6 gamma Polyclonal Antibody

Catalog # :

PA1-723

Quantity :

100 µL

Pricing :

US 428

Clonality :

Polyclonal

Purity :

Ammonium sulfate precipitation

Host :

Rabbit

Reactivity :

Bovine, Ovine

Applications :

Western Blot: 1:500

Species :

Bovine, Ovine

Isotype :

IgG

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.

Immunogen :

Synthetic Peptide: M(1) N L E P P K A E I R S A T R(15) C

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:500

Aliases :

GMP-PDE gamma; p3AT; PDE6G; PDEG; phosphodiesterase 6G; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G; RP57; unnamed protein product