Dynamin 1 Polyclonal Antibody | Invitrogen PA1-660 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Dynamin 1 Polyclonal Antibody

catalog :

PA1-660

quantity :

100 uL

price :

US 491.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; loading ...; fig 1h	Wu Q, Zhang Q, Liu B, Li Y, Wu X, Kuo S, et al. Dynamin 1 Restrains Vesicular Release to a Subquantal Mode In Mammalian Adrenal Chromaffin Cells. J Neurosci. 2019;39:199-211 pubmed publisher
western blot knockout validation; mouse; 1:1500; fig 4 immunoprecipitation; mouse; fig 4	Asinof S, Mahaffey C, Beyer B, Frankel W, BOUMIL R. Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy. Neurobiol Dis. 2016;95:1-11 pubmed publisher
immunocytochemistry; human; fig 5	Yamada H, Takeda T, Michiue H, Abe T, Takei K. Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells. Int J Oncol. 2016;49:877-86 pubmed publisher
	Medina Vera D, Enache D, Tambaro S, Abuhashish E, Rosell Valle C, Winblad B, et al. Translational potential of synaptic alterations in Alzheimer's disease patients and amyloid precursor protein knock-in mice. Brain Commun. 2023;5:fcad001 pubmed publisher
	La T, Tachibana H, Li S, Abe T, Seiriki S, Nagaoka H, et al. Dynamin 1 is important for microtubule organization and stabilization in glomerular podocytes. FASEB J. 2020;34:16449-16463 pubmed publisher
	Daubon T, Guyon J, Raymond A, Dartigues B, Rudewicz J, Ezzoukhry Z, et al. The invasive proteome of glioblastoma revealed by laser-capture microdissection. Neurooncol Adv. 2019;1:vdz029 pubmed publisher
	Nguyen A, Tsika E, Kelly K, Levine N, Chen X, West A, et al. Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. Proc Natl Acad Sci U S A. 2020;117:17296-17307 pubmed publisher
	Mayberry C, Soucy A, Lajoie C, DuShane J, Maginnis M. JC Polyomavirus Entry by Clathrin-Mediated Endocytosis Is Driven by β-Arrestin. J Virol. 2019;93: pubmed publisher
	Fiuza M, Rostosky C, Parkinson G, Bygrave A, Halemani N, Baptista M, et al. PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 Î±-appendage and dynamin. J Cell Biol. 2017;216:3323-3338 pubmed publisher
	Asinof S, Sukoff Rizzo S, Buckley A, Beyer B, Letts V, Frankel W, et al. Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy. PLoS Genet. 2015;11:e1005347 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Dynamin 1 Polyclonal Antibody

Catalog # :

PA1-660

Quantity :

100 uL

Price :

US 491.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: Assay-dependent, Western Blot: 2 ug/mL

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Dynamin is a GTPase required for endocytosis of clathrin coated vesicles from the membrane. Dynamin's involvement in endocytosis was first discovered during the characterization of the temperature sensitive parylytic shibire mutation from Drosophila melanogaster. Three closely related isoforms have been identified in mammals. Dynamin1 is expressed exclusively in neurons, dynamin2 is ubiquitously expressed and dynamin3 is expressed primarily in the testes. Each of these isoforms of dynamin also has several splice variants. This suggests that each isoform/splice variant may have separate intracellular targets or function in the budding of distinct vesicle types. Common domain features of the dynamin proteins include an amino acid terminal GTPase domain, a central pleckstrin homology domain and a highly basic proline rich carboxyl terminus with several Src homology 3 (SH3) domains. These SH3 domains target the dynamin to the clathrin coated pit. Dynamin is known to interact with at least two proteins, AP2 adaptor protein complex and amphiphysin.

Immunogen :

Synthetic Peptide corresponding to resdiues C K(633) E K A S E T E E N G S D S F(647) of rat Dyn1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Western Blot: 2 ug/mL

Aliases :

AI838169; B-dynamin; D100; Dnm; Dnm1; Dyn1; dynamin 1; Dynamin BREDNM19; dynamin i; dynamin, brain; Dynamin1; Dynamin-1; EC 3.6.5.5; EIEE31; Ftfl; Kiaa4093; mKIAA4093; Neuronal dynamin; OTTHUMP00000215500

more info or order :

Invitrogen product webpage