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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
LAMP2 Polyclonal Antibody
catalog :
PA1-655
quantity :
100 uL
price :
US 494.00
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3g
Wani A, Zhu J, ULRICH J, Eteleeb A, Sauerbeck A, Reitz S, et al. Neuronal VCP loss of function recapitulates FTLD-TDP pathology. Cell Rep. 2021;36:109399 pubmed publisher
  • western blot; human; loading ...; fig 1b
Sundararaman A, Fukushima Y, Norman J, Uemura A, Mellor H. RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis. Curr Biol. 2020;30:2146-2155.e5 pubmed publisher
  • immunocytochemistry; domestic rabbit; 1:100; loading ...; fig 6a
Aston D, Capel R, Ford K, Christian H, Mirams G, Rog Zielinska E, et al. High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart. Sci Rep. 2017;7:40620 pubmed publisher
  • western blot; mouse; fig 1a
Su F, Myers V, Knezevic T, Wang J, Gao E, Madesh M, et al. Bcl-2-associated athanogene 3 protects the heart from ischemia/reperfusion injury. JCI Insight. 2016;1:e90931 pubmed publisher
  • western blot; human; 1:10,000; fig 3
Tokuda E, Brännström T, Andersen P, Marklund S. Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase. Acta Neuropathol Commun. 2016;4:6 pubmed publisher
Irmer B, Efing J, Reitnauer L, Angenendt A, Heinrichs S, Schubert A, et al. Extracellular vesicle-associated tyrosine kinase-like orphan receptors ROR1 and ROR2 promote breast cancer progression. Cell Commun Signal. 2023;21:171 pubmed publisher
Cheng K, Chang Y, Chu L, Hsieh S, An L, Dai Z, et al. The Iridoid Glycoside Loganin Modulates Autophagic Flux Following Chronic Constriction Injury-Induced Neuropathic Pain. Int J Mol Sci. 2022;23: pubmed publisher
Wang C, Huang C, Tsai M, Wang C, Chang W, Liu S, et al. Inhaled Carbon Dioxide Improves Neurological Outcomes by Downregulating Hippocampal Autophagy and Apoptosis in an Asphyxia-Induced Cardiac Arrest and Resuscitation Rat Model. J Am Heart Assoc. 2022;11:e027685 pubmed publisher
Piec P, Pons V, Pr xe9 fontaine P, Rivest S. Muramyl Dipeptide Administration Delays Alzheimer's Disease Physiopathology via NOD2 Receptors. Cells. 2022;11: pubmed publisher
Gericke B, Wienb xf6 ker I, Brandes G, L xf6 scher W. Is P-Glycoprotein Functionally Expressed in the Limiting Membrane of Endolysosomes? A Biochemical and Ultrastructural Study in the Rat Liver. Cells. 2022;11: pubmed publisher
You Y, Muraoka S, Jedrychowski M, Hu J, McQuade A, Young Pearse T, et al. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022;11:e12183 pubmed publisher
Lu A, Hsieh F, Sharma B, Vaughn S, Enrich C, Pfeffer S. CRISPR screens for lipid regulators reveal a role for ER-bound SNX13 in lysosomal cholesterol export. J Cell Biol. 2022;221: pubmed publisher
Soundararajan A, Ghag S, Vuda S, Wang T, Pattabiraman P. Cathepsin K Regulates Intraocular Pressure by Modulating Extracellular Matrix Remodeling and Actin-Bundling in the Trabecular Meshwork Outflow Pathway. Cells. 2021;10: pubmed publisher
Ayagama T, Bose S, Capel R, Priestman D, Berridge G, Fischer R, et al. A modified density gradient proteomic-based method to analyze endolysosomal proteins in cardiac tissue. iScience. 2021;24:102949 pubmed publisher
Davis S, Roth J, Aljabi Q, Hakim A, Savell K, Day J, et al. Delivering progranulin to neuronal lysosomes protects against excitotoxicity. J Biol Chem. 2021;:100993 pubmed publisher
Nieto Torres J, Shanahan S, Chassefeyre R, Chaiamarit T, Zaretski S, Landeras Bueno S, et al. LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes. Curr Biol. 2021;31:3440-3449.e7 pubmed publisher
Sudhakar J, Lu H, Chiang H, Suen C, Hwang M, Wu S, et al. Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas. Nat Commun. 2020;11:4286 pubmed publisher
Kwon I. Protective effects of endurance exercise on skeletal muscle remodeling against doxorubicin-induced myotoxicity in mice. Phys Act Nutr. 2020;24:11-21 pubmed publisher
Puangmalai N, Bhatt N, Montalbano M, Sengupta U, Gaikwad S, Ventura F, et al. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell Death Dis. 2020;11:314 pubmed publisher
Liu M, Pi H, Xi Y, Wang L, Tian L, Chen M, et al. KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity. Autophagy. 2021;17:903-924 pubmed publisher
Cui L, Zhao L, Ye J, Yang L, Huang Y, Jiang X, et al. The Lysosomal Membrane Protein Lamp2 Alleviates Lysosomal Cell Death by Promoting Autophagic Flux in Ischemic Cardiomyocytes. Front Cell Dev Biol. 2020;8:31 pubmed publisher
Cursano S, Battaglia C, Urrutia Ruiz C, Grabrucker S, Schön M, Bockmann J, et al. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Mol Psychiatry. 2020;: pubmed publisher
Zhou J, Waskowicz L, Lim A, Liao X, Lian B, Masamune H, et al. A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. Thyroid. 2019;29:1158-1167 pubmed publisher
Perea Gomez A, Cases O, Lelievre V, Pulina M, Collignon J, Hadjantonakis A, et al. Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse. Sci Rep. 2019;9:10168 pubmed publisher
Colleluori G, Aguirre L, Phadnis U, Fowler K, Armamento Villareal R, Sun Z, et al. Aerobic Plus Resistance Exercise in Obese Older Adults Improves Muscle Protein Synthesis and Preserves Myocellular Quality Despite Weight Loss. Cell Metab. 2019;30:261-273.e6 pubmed publisher
Abdullah C, Alam S, Aishwarya R, Miriyala S, Bhuiyan M, Panchatcharam M, et al. Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Sci Rep. 2019;9:2002 pubmed publisher
Singhal A, Szente L, Hildreth J, Song B. Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1. Cell Death Dis. 2018;9:1019 pubmed publisher
Russo R, Varano G, Adornetto A, Nazio F, Tettamanti G, Girardello R, et al. Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival. Cell Death Dis. 2018;9:981 pubmed publisher
Zhang L, Zhang P, Wang G, Zhang H, Zhang Y, Yu Y, et al. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018;98:783-800.e4 pubmed publisher
Adachi N, Suzuki S, Matsuoka H, Fushimi S, Ono J, Ohta K, et al. Corticotropin-releasing hormone-binding protein is up-regulated by brain-derived neurotrophic factor and is secreted in an activity-dependent manner in rat cerebral cortical neurons. J Neurochem. 2018;: pubmed publisher
Berth S, Caicedo H, Sarma T, Morfini G, Brady S. Internalization and axonal transport of the HIV glycoprotein gp120. ASN Neuro. 2015;7: pubmed publisher
product information
Product Type :
Antibody
Product Name :
LAMP2 Polyclonal Antibody
Catalog # :
PA1-655
Quantity :
100 uL
Price :
US 494.00
Clonality :
Polyclonal
Purity :
Antigen affinity chromatography
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:100-1:1,000
Species :
Human, Mouse, Rat
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
LAMP2 (Lysosome-associated membrane glycoprotein 2, CD107b) is a member of a family of membrane glycoproteins. LAMP2 provides selectins with carbohydrate ligands, and may play a role in tumor cell metastasis, and have a function in the protection, maintenance, and adhesion of the lysosome. Prior to posttranslational modification, LAMP2 is approximately 46 kDa polypeptide. Mature, functional LAMP2 is extensively glycosylated with a variety of different N-linked and O-linked oligosaccharides with a total molecular weight of about 100-130 kDa. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. LAMP2 is used to monitor a very selective form of autophagy called chaperone-mediated autophagy. LAMP 2 has a structure comprised of a large amino-terminal intra-lysosomal domain, a hydrophobic trans-membrane domain, and a short carboxyl-terminal cytoplasmic tail. The LAMP protein has 3 variant forms: LAMP-2A, -2B, and 2C. LAMP2, together with CD107a/LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, and LAMP2 is an important regulator in successful phagosomal maturation. LAMP2 deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danon’s disease).
Immunogen :
Synthetic Peptide: C G(400) L K R H H T G Y E Q F(411)
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): 1:20, Western Blot: 1:100-1:1,000
Aliases :
CD107 antigen-like family member B; CD107b; EGK_20887; Igp96; Lamp II; LAMP2; LAMP-2; LAMP-2 Isoform 2A; LAMP-2 Variant A; Lamp-2a; Lamp-2b; Lamp-2c; LAMPB; LGP110; LGP-110; LGP-96; LGP-B; lysosomal associated membrane protein 2; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; Mac3; RP23-193O17.2
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA